This volume covers contemporary advances in five important areas of
pharmacology and medicinal chemistry including: a comprehensive
account of inhibitors of the caspase family of proteolytic enzymes
that represent a new class of anti-inflammatory and antiapoptotic
agents of potential value in rheumatoid arthritis, and other
peripheral and central indications; adoc umented survey of
semi-synthetic and totally synthetic antibiotics and anti HIV
agents and their sites of interaction; inhibitors of the
intracellular enzyme acyl-CoA: cholesterol O-acyltransferase (ACAT)
developed for the treatment of hypercholesterolemia; and recent
progress in growth hormone secretagogues, with the focus on
strategies to improve oral bioavailability and duration of action.
Inhibition of the proteolytic enzyme, hepatitis C protease
N-3(NS3), required for viral replication, is one of the most
attractive targets for HCV infections. Progress and prospects in
the design of peptide and non-peptide inhibitors are described
here. design and clinical potential of new drug molecules; valuable
summaries of structure-activity relationships in topical areas of
medicinal chemistry; and extensive references to the biology,
medicinal chemistry and clinical aspects of each topic.
General
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