The human life has always been in danger from diseases caused by
microorganisms. Great attention has been paid to bacterial fight to
antibiotics in both human beings and animal populations for its
adverse impacts on morbidity and mortality from diseases caused by
resistant bacteria. It also causes economic costs of therapy and
real risks of the spread of resistant strains among animals and
humans.Administration of third generation Cephalosporins and
Aztreonam in an infection with confirmed ESBL producers would be
disastrous, because this would not only be ineffective thus
increasing mortality but simultaneously promoting ESBLs production
and leading to increased resistance.Emergence of
metallo-beta-lactamase-mediated resistance in Pakistan is a matter
of great concern. Carbapenems are effective therapeutic agents
against highly resistant pathogens like Pseudomonas spp. and
Acinetobacter spp. Spread of this resistance among these pathogens
and transfer to other Gram-negative bacteria would seriously
restrict our therapeutic options.
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