Major depressive disorders have recently been associated with
impairments in signaling pathways that regulate neuroplasticity and
cell survival. Agents designed to directly target molecules in
these pathways hold promise as new therapeutics for depression.
With the collaboration of the most prestigious international
specialists in biochemistry, molecular biology, genomics,
psychiatry, psychology, and pharmacology, Neurobiology of
Depression discusses the nature of the central nervous system
circuits responsible for the modifications of neuronal functioning
that lead to depression.
The book begins by discussing animal, neurophysiological, and
neuropsychological models of depression as well as neural
foundations. It explores genetic factors that contribute to
depression and describes the effect of monoaminergic systems in the
central nervous system.
Next, the book profiles the rise of psychopharmacology in the
treatment of depression and the research into serotonin and
monoamine reuptake inhibitors. It examines the role of the
glutamatergic, endocannabinoid, and opioid systems in the
pathophysiology of mood disorders, as well as the effect of
biological rhythms on the human body.
Later chapters review the role of CRF-related ligands, CRF
receptors, HPA axis activity, and glucocorticoid receptors in the
regulation of the stress response and depression. They also
describe cytokine modulation of molecular mechanisms. They examine
the role of neuropeptide Y, nitric oxide, beta-arrestins, BDNF, and
phosphodiesterases, and discuss the use of tachykinin antagonists
in treatment. Finally, they analyze the neurobiological basis for
the development of new antidepressant agents.
Exploring myriad aspects of a disease that plagues a large
percentage of the population worldwide, this volume captures the
state of the science of this debilitating disorder, facilitating
further research and discovery.
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