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Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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Kidney in Essential Hypertension - Proceedings of the Course on the Kidney in Essential Hypertension held at New Orleans, Louisiana, March 18-19, 1983 (Hardcover, 1984 ed.)
Loot Price: R3,087
Discovery Miles 30 870
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Kidney in Essential Hypertension - Proceedings of the Course on the Kidney in Essential Hypertension held at New Orleans, Louisiana, March 18-19, 1983 (Hardcover, 1984 ed.)
Series: Developments in Cardiovascular Medicine, 35
Expected to ship within 10 - 15 working days
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The kidney, similar to the heart, plays a three-fold role in
essential hypertension. First, it participates in the patho genesis
of arterial hypertension. Second, it suffers as a target organ of
long-standing hypertension, and third, it experiences the effects
of antihypertensive therapy. Perhaps most contested at the present
time is the involvement of the kidney in the patho genesis of
essential hypertension. More than a century ago, William Osler put
forward three basic hypotheses about the "genuine contracted
kidney. "l 1. "The hypertrophy can be regarded as an effect to
overcome a sort of stop-cock action of the vessels when under the
influence of an irritating ingredient in the blood greatly
contracted and increased the peripheral resistance. " Clearly this
hypothesis of an "irritating ingredient" is perhaps the most
convincing nowadays, and numerous attempts have been made to
identify a specific vasoconstrictive agent in the blood in
essential hypertension. 2. "The obliteration of a large number of
capillary territories in the kidney materially raised the arterial
pressure. An additional factor of dimin ished excretion of water
also heightened the pressure within the blood vessel. " Today we
know that fluid volume overload in the presence of reduced renal
mass seems to be the most likely mechanism accoun ting for renal
parenchymal hypertension and, as shown by Guyton's group, for
certain forms of experimental hypertension. 3."
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