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Protein Chromatography - Process Development and Scale-Up 2e (Hardcover, 2nd Edition)
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Protein Chromatography - Process Development and Scale-Up 2e (Hardcover, 2nd Edition)
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An all-in-one practical guide on how to efficiently use
chromatographic separation methods Based on a training course that
teaches the theoretical as well as practical aspects of protein
bioseparation to bioprocess professionals, this fully updated and
revised new edition offers comprehensive coverage of continuous
chromatography and provides readers with many relevant examples
from the biopharmaceutical industry. Divided into two large parts,
Protein Chromatography: Process Development and Scale-Up, Second
Edition presents all the necessary knowledge for effective process
development in chromatographic bioseparation, both on small and
large scale. The first part introduces chromatographic theory,
including process design principles, to enable the reader to
rationalize the set-up of a bioseparation process. The second part
illustrates by way of case studies and sample protocols how the
theory learned in the first part may be applied to real-life
problems. Chapters look at: Downstream Processing of Biotechnology
Products; Chromatography Media; Laboratory and Process Columns and
Equipment; Adsorption Equilibrium; Rate Processes; and Dynamics of
Chromatography Columns. The book closes with chapters on: Effects
of Dispersion and Rate Processes on Column Performance; Gradient
Elution Chromatography; and Chromatographic Column Design and
Optimization. -Presents the most pertinent examples from the
biopharmaceutical industry, including monoclonal antibodies
-Provides an overview of the field along with design tools and
examples illustrating the advantages of continuous processing in
biopharmaceutical productions -Focuses on process development and
large-scale bioseparation tasks, making it an ideal guide for the
professional bioengineer in the biotech and pharma industries
-Offers field-tested information based on decades of training
courses for biotech and chemical engineers in Europe and the U.S.
Protein Chromatography: Process Development and Scale-Up, Second
Edition will appeal to biotechnologists, analytical chemists,
chromatographers, chemical engineers, pharmaceutical industry,
biotechnological industry, and biochemists.
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