Modulation of MHC Antigen Expression and Disease (Paperback)

The major histocompatibility complex (MHC) genes are involved in the immune system's response to tumor and infected cells and in generating an immune response. This book brings together basic aspects of the regulation of MHC antigens with important clinical applications (in viral infection, viral oncology, cancer biology and autoimmunity). There is a strong emphasis on situations where MHC expression is modulated (either stimulated or repressed). The book's major themes are: the mechanisms of MHC expression--explored at several levels including the transcription and translation of MHC genes and the insertion of MHC protein molecules into plasma membranes; the effect of cytokines on MHC expression--both in the etiology of certain diseases and in possible immunotherapeutic approaches to disease; and the use of gene therapy to modify MHC expression in cancer cells, and thereby cause tumor rejection. This book will be valuable to researchers and clinicians in molecular biology, immunology, oncology, and virology.

General

Imprint:	Cambridge UniversityPress
Country of origin:	United Kingdom
Release date:	November 2005
First published:	1995
Editors:	G. Eric Blair • Craig R. Pringle • D. John Maudsley
Dimensions:	234 x 156 x 25mm (L x W x T)
Format:	Paperback - Trade
Pages:	460
ISBN-13:	978-0-521-49921-7
Categories:	Books > Science & Mathematics > Biology, life sciences > Developmental biology
LSN:	0-521-49921-6
Barcode:	9780521499217

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