In gastrointestinal (GI) practice, a large proportion of patients
present with what are currently classified as functional GI
complaints. For decades, psychological causes have been implicated
in the initiation and maintenance of symptoms. In recent years,
disturbances of GI function including sensory motor abnormalities
have been catalogued and are now believed to play a key role in the
development of symptoms. A genetic predisposition may be important.
Furthermore, evidence has accumulated that GI inflammation can
trigger and maintains functional disturbances. In particular, acute
GI inflammation appears to play a crucial role in at least a
subgroup of patients. These observations potentially have profound
implications for the field, and suggest that functional GI
disorders are indeed organic diseases.
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