Radiochemical methodology constitutes the most important base for
the successful functioning of a PET group in the routine production
and development of radiopharmaceuticals. Of the several hundred
products which have been labelled with positron emitters during the
past two decades about 35 are presently considered to be of major
interest. The time for a state-of-the-art review is right, since
this field has advanced over the past fifteen years to reach a
level where guidelines can now be suggested. Chapters of this book
deal with each of the main methodological aspects of the chemistry
needed to develop an effective radiopharmaceutical, namely
radionuclide production, automation and metabolite analysis. A
further chapter on QA/QC is written by a broadly-based expert group
and is meant to provide a guideline and a base for future
monographs and regulations on major PET radiopharmaceuticals of
today. This book will help the increasing numbers of scientists who
are now entering the field of PET to appreciate the methodological
aspects that are normally addressed by chemists in relation to PET
radiopharmaceuticals; it provides many useful practical guidelines
and will promote early success in their own endeavours, since these
will often necessarily begin by establishing chemical methodology
of the kind discussed here.
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