Optimization in Drug Discovery - In Vitro Methods (Hardcover, 2nd ed. 2014)

Thoroughly revised and updated, "Optimization in Drug Discovery: In Vitro Methods, Second Edition" presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the "Methods in Pharmacology and Toxicology" series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Expert authors have developed and utilized these in vitro assays to achieve drug-like characteristics in addition to efficacy properties and good safety profiles of drug candidates.

Comprehensive and up-to-date, "Optimization in Drug Discovery: In Vitro Methods, Second Edition" aims to guide researchers down the difficult path to successful drug discovery and development."

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