Extended release of solid dispersion of water soluble PHC was
successively prepared by coevaporation with Eudragit RLPO in 1: 5
ratios. The sustainment of drug release was effected by
drug-polymer ratio and method of preparation. The analysis by
spectral techniques (FT-IR, FT-NMR) suggested possibility of
hydrogen bonding. The results of DSC, XRD and SEM studies revealed
the reduction in crystallinity of pure drug in solid dispersions as
compared to their physical mixtures. The results of solubility
studies were in accordance with the in vitro release profile and
the order of sustainment of drug release was found in rank order of
0.1 N HCl (pH 1.2)
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