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Preparation and Solid-State Characterization of Leflunomide Polymorph (Paperback)
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Preparation and Solid-State Characterization of Leflunomide Polymorph (Paperback)
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Leflunomide is a drug with limited water solubility. It exhibits
four polymorphic forms I, II, III, IV. In the present study, form
II polymorph was formulated using form I. Form II polymorph readily
dissolves in water than does form I. The crystals of form I and II
polymorph were characterized by IR, DSC, XRPD. Comparison of
solubility of form I and form II was done by UV Spectrophotometer.
There was a significant increase in solubility of form II. Aqueous
film-coated tablets of form I and form II were prepared using the
same processing parameters and compared for the rate of
dissolution. Form II tablets showed a significant improvement in
terms of dissolution rate, drug release and solubili
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