NETosis: Immunity, Pathogenesis and Therapeutics takes a focused
approach to the clinical aspects of NETosis and drug development,
bringing critical findings. Chapters introduce NETosis, consider
mechanisms and antimicrobial strategies regulating NETosis, examine
NETosis in neonates, explore the role of NETosis in autoimmunity,
delve into NETosis and other diseases, and present therapeutic
approaches for dysregulated NETosis. Since Brinkamm, et al,
discovered an unrecognized neutrophil anti-microbial mechanism
responsible for the extracellular killing of invading pathogens in
2004, the novel process in which nuclear chromatin de-condenses and
DNA is ejected into the extra cellular environment, trapping and
inactivating tissue pathogens has rapidly evolved.
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