During the past ten years, several theories have been proposed
on the origin of the diversity of antibodies. George P. Smith
presents a critical study of these theories in this detailed
treatment of immunological problems from the point of view of
molecular genetics.
Mr. Smith uses a new and simplifying approach to this
long-standing controversy. By a comprehensive computerized analysis
of antibody amino acid sequences (particularly the myeloma
proteins), the author traces their evolution and matches his
results against the expectations of the various theories of
diversity. He discusses at length the other types of evidence as
well.
Mr. Smith also deals with the clonal specialization of cells to
produce a single antibody, and the relationship of this
specialization to the somatic joining of antibody half-genes, which
is one of the immune system's most important peculiarities.
Introductory material is provided to make this work
understandable to molecular geneticists not versed in immunology
and to immunologists not versed in molecular genetics.
This is a timely book offering a succinct and coherent summary
of the various lines of evidence in a confused and controversial
field.
General
Imprint: |
Harvard University Press
|
Country of origin: |
United States |
Release date: |
April 2014 |
First published: |
October 2013 |
Authors: |
George P Smith
|
Dimensions: |
234 x 156 x 14mm (L x W x T) |
Format: |
Hardcover - Sewn / Cloth over boards
|
Pages: |
236 |
ISBN-13: |
978-0-674-36513-1 |
Categories: |
Books >
Science & Mathematics >
Biology, life sciences >
General
|
LSN: |
0-674-36513-5 |
Barcode: |
9780674365131 |
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