The neuronal cytoskeleton is a complex structure responsive to both
intrinsic and extrinsic factors. Defined populations of neurons in
the brains of patients with Alzheimer and several other
neurodegenerative diseases contain abnormal filamentous
accumulations which share elements with the cytoskeleton. Although
there is a general consensus that these abnormal filaments do
contain cytoskeletal elements, much debate remains regarding which
cytoskeletal elements are incorporated and whether the cytoskeletal
rearrangement is primary or secondary to other cellular changes. In
this book these questions are addressed in a historical perspect
ive in light of new data that allows the reinterpretation of
previously reported results. Contributions are based on many of the
major tech niques of modern biology including biochemistry,
molecular biology, electron microscopy and immunocytochemistry. In
the view of the editor, this volume is being written at a time when
our understanding of the cytopathology of Alzheimer disease is
moving from predominantly descriptive to both analytical and
mechanistic. I hope that this contribution will provide impetus to
speed this transi tion. George Perry Cleveland, Ohio vii
ACKNOWLEDGEMENT The support of the Fidia Pharmaceutic Corporation
for the computer generated color figure on page 65 is gratefully
acknowledged.
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