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Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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Alterations of Excitation-Contraction Coupling in the Failing Human Heart (Paperback, Softcover reprint of the original 1st ed. 1998)
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Alterations of Excitation-Contraction Coupling in the Failing Human Heart (Paperback, Softcover reprint of the original 1st ed. 1998)
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Alteration of excitation-contraction coupling in the failing human
heart was deemed an interesting subject for a dialogue between
basic scientists and clinical researchers in continuation of
previous Gargellen Conferences concerned with the function of the
normal and failing human myocardium. In 1987 basic mechanisms and
clinical implications of then new insights into cardiac energetics
was followed by a comprehensive review of inotropic stimulation and
myocardial energetics in 1989. Here, we undertook a re-evaluation
of the principles of inotropic stimulation and of its potential
therapeutic value, based on new observa tions from experiments with
human myocardium. In 1992 the risk due to myocardial phenotype
change as a consequence of adaptation in heart failure was
published. Here, alterations of subcellular structures and
functions as a consequence of chronic heart failure, summarized as
phenotype change, could be described as an essential characteristic
of the failing human myocardium. This topic was discussed in
greater depth in the volume "Cellular and Molecular Alterations in
the Failing Human Heart," considering both the sarcolemma and the
phosphodiesterases, as well as excitation-contraction coupling and
contractile proteins, extracellular matrix, and mitrochondrial
function."
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