Following an opening chapter by the late Susumu Ohno on
paralogues of sex-determining genes, the five best-studied genes
essential for early mammalian gonadal development are portrayed in
detail: SF-1 and WT1 and their roles in early events in gonadal
development, SRY and SOX9 in testis determination, and the
anti-testis gene DAX-1. Subsequent chapters look at the roles of
these genes in sex determination in marsupial mammals, birds,
reptiles, amphibians and fish, and review the different
sex-determining mechanisms, genetic and environmental, that operate
in these different vertebrate classes. Two insights emerge: one,
that the same basic set of genes appears to operate during early
gonadal development in all vertebrates, despite the differences in
mechanisms; the other, that sex determination in vertebrates
results from a complex network of regulatory interactions and not
from a simple hierarchical cascade of gene actions.
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