The aim of this book was to provide basic knowledge of the art for
the development of controlled release matrix tablets of diclofenac
sodium with synthetic (Hydroxypropyl Methyl Cellulose) and natural
(Xanthine Gum) hydrophilic polymers using different concentrations
by direct compression technique and to comparatively evaluate the
formulations on the basis of in-vitro and in-vivo parameters. An
in-vivo study was conducted on rabbits and the results were
calculated using different software like SPSS and Kinetica. In
conventional pharmaceutics, matrix based tablet formulations are
considered economical and easy to manufacture. This book would be
helpful for the students who are involved in the matrix based
formulation development at MS and PhD level.
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