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Books > Medicine > Clinical & internal medicine > Haematology
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Mechanisms in Myeloid Tumorigenesis 1988 - Workshop at the National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, March 22, 1988 (Paperback, Softcover reprint of the original 1st ed. 1989)
Loot Price: R2,765
Discovery Miles 27 650
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Mechanisms in Myeloid Tumorigenesis 1988 - Workshop at the National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, March 22, 1988 (Paperback, Softcover reprint of the original 1st ed. 1989)
Series: Current Topics in Microbiology and Immunology, 149
Expected to ship within 10 - 15 working days
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Through numerous discussions with colleagues it became apparent
that the time was right to begin a series of workshop-like meetings
on myeloid tumorigenesis. Myeloid tumors are the nonlymphocytic
tumors of the hematopoietic system which include tumors of the
neutrophilic, monocytic, erythrocytic, basophilic (mast cell) and
megakaryocytic lineages. Pioneering studies in myeloid
tumorigenesis were initially made in chickens with the discovery of
retroviruses that induce various kinds of myeloid tumors acutely
(myelocytomatosis, myeloblastosis, and erythroblastosis). These
avian retroviruses were subsequently shown to contain the oncogenes
v-myb, v-~, v-~, v-erbA, or v-erbB. There have been dramatic
advances in studying the pathogenesis of hematopoietic tumors in
genetically defined mammalian systems. Many of the well developed
model systems in inbred mice, have focused on T- and B-1ymphoma
development. Although myeloid tumors have been found in mice, they
have not been studied as intensively as lymphoid tumors. Possibly
this is because myeloid tumors are less common than lymphoid
tumors. Recently, there has been renewed interest in murine myeloid
tumor systems. This focus has resulted from 1) the discovery of
inbred strains of mice (e. g. BXH-2, AKXD- 23, SJL/J) that are
highly susceptible to spontaneous or induced myeloid tumorigenesis;
2) establishment of transplantable murine myeloid tumors (e.
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