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Arthritis - Models and Mechanisms (Paperback)
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Arthritis - Models and Mechanisms (Paperback)
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Rheumatoid arthritis is a common disease, an estimated 1. 5% of the
population being under medical treatment for it in European
countries and elsewhere. However, to date the origin of this
chronic inflammatory disorder has not been elucidated. Evidence for
the involvement of microbial agents is still tenuous, the rea- son
for the defective control of inflammation is still unknown, and the
disease all too of- ten progresses to crippling stages despite
long-term treatment. As T. McKeown recently stated with regard to
rheumatoid arthritis, "not enough is even known to indicate which
is the more promising approach, and the pru- dent course is to
investigate both origins and mechanisms". While working on animal
model diseases as well as on aspects of rheumatoid arthritis and
related disorders in man, the members of the Special Research Area
on patho- physiology of rheumatoid inflammation in man and. animals
(Sonderforschungsbereich 54 "Pa- thomechanismen der rheumatoiden
Entztindung bei Mensch und Tier"; maintained by the Deut- sche
Forschungsgemeinschaft) at the Veterinary and Medical Schools,
Hannover, have been guided by the concept that by studying
clinically and morphologically similar diseases in several species,
mutually stimulating results might lead to improved knowledge of
the pathophysio- logy of rheumatoid arthritis. In particular, from
working with model diseases in animals new approaches to the
etiology of rheumatoid arthritis might be derived, while detailed
knowledge of pathogenetic processes in rheu- matoid arthritis could
further research in chronic stages of pertinent animal diseases.
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