Molecules of biological interest for in-vivo and in-vitro
research or diagnostics of metabolic functions and of
neuro-transmission are very often labeled with iodine. Based on
state-of-the-art research, this compendium describes the major
production routes of the six most relevant iodine radio isotopes
and the various methods of labeling molecules of biological,
diagnostic or pharmaceutical interest with them.
The chapters describe the basic reaction mechanisms, and the
influence of iodine introduction on physical/chemical and
pharmacological properties. They also include examples of important
reaction pathways for the preparation of radio-iodine compounds.
The volume is completed by an expert system providing guidelines to
obtain the most suitable method of synthesis regarding also cost
and time aspects. Worked examples support the novices confronted
with radio-iodination reactions.
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