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The Human Thymus - Histophysiology and Pathology (Paperback, Softcover reprint of the original 1st ed. 1986)
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The Human Thymus - Histophysiology and Pathology (Paperback, Softcover reprint of the original 1st ed. 1986)
Series: Current Topics in Pathology, 75
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Twenty-five years have passed since J. MILLER'S basic work on the
central role of the thymus for the generation of immunological
reactivi ty. During this time, the abundance of fascinating
literature on the immunological and functional aspects of this
organ has been in contrast to the paucity of reports on its role in
pathology. The causal or formal pathogenesis even of many of the
well-documented pathological fea tures is so far unexplained or at
least uncertain. In spite of some concep tual progress related to
the work of CASTLEMAN, LEVINE, and ROSAI, we regrettably have to
say that in pathology the thymus remains almost as inconspicuous as
25 years ago. Only the new techniques developed in recent years
have made it possible to look as closely into the complicated
structural organization of the thymus as it appears to be necessary
to observe and document abnormalities. Major steps have been taken
with the advent of mono clonal antibody immune histochemistry and
with detailed ultrastructur al studies in embryology. At this
point, pathologists and researchers with a special interest in the
thymus were asked to give overviews of their respective fields of
interest in light of recent findings in immunology and basic
insights into the structural-functional interrelationship of the
human thymus. The results of this initiative have been brought
together in this volume.
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