Infection with the human immunodeficiency virus is characterized by
the destruction of the host immune system as also reflected by a
progressive loss of CD4-positive T-cells. This finally results in
the host's incapacity to deal with opportunistic infections and the
immune surveillance of tumors, a clinical status known as the
Acquired Immunodeficiency Syndrome (AIDS). The book AIDS
Pathogenesis provides the reader with a complete overview of the
clinical course of HIV-1 infection. It describes the clinical
aspects of primary infection, the different clinical outcomes of
HIV-1 infection, and strategies for anti-viral treatment. In
addition, more fundamental aspects of HIV-1 infection are reviewed.
These include the biology of the virus and the novel insights in
AIDS pathogenesis. Not only is the significance of an HIV-specific
cellular and humoral immune response discussed, but also the
possible incapacity of the adult human host to deal with T-cell
destruction. Finally, the book discusses the currently used
laboratory markers that allow for monitoring of the clinical course
of infection.
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