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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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IgM and Its Receptors and Binding Proteins (Hardcover, 1st ed. 2017)
Loot Price: R3,856
Discovery Miles 38 560
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IgM and Its Receptors and Binding Proteins (Hardcover, 1st ed. 2017)
Series: Current Topics in Microbiology and Immunology, 408
Expected to ship within 12 - 17 working days
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Total price: R3,876
Discovery Miles: 38 760
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This volume reviews the current state of research on the IgM
antibody and its multiple receptors and binding proteins.
Interactions of the IgM ligands with these molecules are important
for protection against infections as a first line of defense, as
well as for regulation of immune responses to pathogens and
self-antigens. The book includes up-to-date information on: (i) the
phylogeny of three IgM-binding receptors [polymeric Ig receptor
(pIgR), Fc receptor for both IgA and IgM (Fc /R), and Fc receptor
for IgM only (FcR)]; (ii) the lymphocyte-restricted distribution
and unique ligand-binding activity of FcR; (iii) the definition and
potential function of Fc receptor-like molecule A (FCRLA) as a
resident endoplasmic reticulum protein that binds IgM, but also IgG
and IgA; (iv) IgM antibody-mediated enhancement of humoral immune
responses, highlighting the importance of complement and its
receptors, (v) the numerous important roles of IgM natural
antibodies in regulation of inflammation. It is an invaluable
resource for researchers and clinicians alike.
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