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Books > Medicine > Clinical & internal medicine > Rheumatology
Comprised exclusively of clinical cases involving osteonecrosis of the femoral head (ONFH), this concise, practical casebook will provide orthopedic surgeons with the best real-world strategies to properly diagnose and treat both pre- and post-collapse conditions. Each chapter is a case that opens with a unique clinical presentation, followed by a description of the diagnosis, assessment and management techniques used to treat it, as well as the case outcome and clinical pearls and pitfalls. Part I discusses pre-collapse treatments aimed at the early stages of ONFH, including the use of bisphosphonates, stem cell therapy and minimally invasive core decompression. Chapters presenting post-collapse treatments aimed at preserving the femoral head comprise part II, including non-vascularized bone grafting, osteochondral transfer and transtrochanteric osteotomy. Cases covering post-collapse total hip arthroplasty (THA) and common complications round out the presentation. Osteonecrosis of the Femoral Head: A Clinical Casebook will be an excellent resource for orthopedic surgeons, residents and fellows treating hip pain.
This book covers recent advances in the use of electrostimulation therapies in movement disorders, epilepsy, inflammatory bowel disease, memory and cognition, disorders of consciousness, foot drop, dysphagia, brain injury, headache, heart failure, hearing loss, and rheumatoid arthritis. It describes techniques such as vagus nerve stimulation, deep brain stimulation, and electrical stimulation of the pharyngeal nerve. Electroceuticals: Advances in Electrostimulation Therapies is aimed at clinicians and basic researchers in the fields of neurology, neurosurgery, cardiology and rheumatology.
This book discusses the role of patient reported outcome measures (PROMs) in the diagnosis and management of rheumatic diseases and their implementation in patient-centered care. It aims to improve the quality and efficiency of patient care in standard practice by outlining the appropriate information-gathering and decision-making processes. The book highlights the evidence and advanced knowledge base of PROMs in rheumatic diseases such as rheumatoid arthritis, systemic lupus erythematosus, juvenile idiopathic arthritis, osteoarthritis, and systemic sclerosis. Featuring reviews of Patient Reported Outcome tools and Physician RheuMetric Measures as well as examples of patient reported outcome questionnaires, Patient Reported Outcome Measures in Rheumatic Diseases serves as an excellent introduction and resource for implementation of PROMs in clinical rheumatology practice.
This fully updated and extended second edition provides a comprehensive overview on the basic concepts of the rapidly developing field of osteoimmunology and also offers in-depth insights into the molecular mechanisms of bone diseases. Clinical data is presented and put into context with the latest research findings. This second edition in addition discusses the latest topics in transplantation immunology. The book addresses scientists and physicians working in immunology, pathophysiology and osteology.
The second edition of this well-received book reflects the state of the art in surgery for malignant bone tumors in children, with a particular focus on epiphysiolysis before excision. With a thorough update, new chapters, a clear presentation of tips and tricks to address complications, as well as supplementary online videos and tutorials, this book addresses the challenges of limb preservation that are posed to the surgeon in this new era of cancer treatment characterized by higher survival rates and longer survival times. The authors are experienced practitioners of Canadell's technique, but the book also explores, thanks to the focused contributions of experts from other fields of medicine, a range of topics from the molecular biology and histological aspects of bone tumors, to the use of imaging techniques and surgical options for epiphyseal preservation. Abundant illustrations and accounts of clinical results make this book an indispensable guide for orthopedic surgeons and pediatric oncologists and give the book an interdisciplinary appeal to practitioners in more general orthopedics, oncology, pediatrics and surgery.
Providing a detailed review of one of the most common clinical problems, elbow instability, this comprehensive text organizes the most up-to-date, evidence-based information on the rapidly advancing field of elbow surgery. Initial chapters focus on anatomy, biomechanics and the most currently utilized surgical approaches for the treatment of the unstable elbow. Subsequent chapters focus on the evaluation and surgical treatments of acute instabilities, such as simple dislocations and fracture-dislocations, as well as chronic instabilities, including chapters focusing on the non-operative and operative management of the throwing athlete. The final chapters describe additional treatment strategies for complex instabilities, focusing on external fixation, total elbow arthroplasty and elbow fusion. Each chapter includes background information, an evaluation section, a treatment algorithm, non-operative treatment strategies, surgical management, published outcomes and preferred methods of treatment from each author. A supplemental video section is also included, depicting frequently performed procedures. Written by experts in the field, The Unstable Elbow consolidates all of the current knowledge of elbow instability into a valuable resource for orthopedic surgeons and residents worldwide.
Key Features * Features concise yet thorough description of the landmark studies and scientific breakthroughs coupled with easy-to-follow organizational structure of chapters that are accessible to readers at different levels of training. * Brings together world-leading experts to provide a fresh perspective to trainees such as residents and fellows-in-training, as well as more senior clinicians and researchers across the field of rheumatology and in specialties such as cardiology, dermatology, pulmonology, nephrology, and neurology, all of whom care for patients with rheumatologic conditions. * Allows the author to imagine and speculate about the evolution of this field in the coming decades. Examples of such speculative possibilities include use of synovial biopsy to predict response to treatment in rheumatoid arthritis, replacement of renal biopsy with urinary proteomics in diagnosing and classifying lupus nephritis, use of new therapeutics to obviate the need for steroids in the treatment of ANCA-associated vasculitis, use of machine learning to evaluate subtle changes in imaging in management of inflammatory arthritis, etc.
This book provides comprehensive coverage of the management and related surgery of the rheumatoid hand, wrist, and elbow. It provides a much-needed, authoritative discussion of the epidemiology, surgical techniques, and outcomes of rheumatoid surgery. The book begins by introducing important background concepts, and then goes on to present up-to-date details on pre and postoperative management, indications, and treatment options. Each section ends with case-based coverage of common clinical scenarios and features numerous illustrations that showcase the sequential approach in managing this disease. Clinical Management of the Rheumatoid Hand, Wrist, and Elbow has broad appeal for rheumatologists and primary care physicians, and will assist them in providing appropriate referrals for surgery consultations. It also serves as a valuable reference for surgeons treating and managing patients with this unique disease.
This book provides an overview of the discovery and structure of IL-17, including its pathogenesis and role in chronic inflammation and autoimmunity. To capture the latest developments and product approvals the book also discusses the therapeutic advances and looks at emerging therapies targeting the IL-17 pathway. IL-17 is a pro-inflammatory cytokine that has a key role in inflammation, autoimmunity, and host defense in a number of inflammatory disorders such as rheumatoid arthritis, psoriatic arthritis and psoriasis, ankylosing spondylitis, multiple sclerosis, and inflammatory bowel disease. The discovery of the IL-17-Th17 pathway has seen exciting development in the field of immunology and inflammation research, which has led to a number of recent regulatory approvals.
Myasthenia Gravis is a neuromuscular disease, caused by an auto-immune process interfering with the acetylcholine receptors at the postsynaptic membrane of the muscle. This book provides guidance on diagnosing the disease, as early diagnosis is important for the application of therapy.
Key Features * Features concise yet thorough description of the landmark studies and scientific breakthroughs coupled with easy-to-follow organizational structure of chapters that are accessible to readers at different levels of training. * Brings together world-leading experts to provide a fresh perspective to trainees such as residents and fellows-in-training, as well as more senior clinicians and researchers across the field of rheumatology and in specialties such as cardiology, dermatology, pulmonology, nephrology, and neurology, all of whom care for patients with rheumatologic conditions. * Allows the author to imagine and speculate about the evolution of this field in the coming decades. Examples of such speculative possibilities include use of synovial biopsy to predict response to treatment in rheumatoid arthritis, replacement of renal biopsy with urinary proteomics in diagnosing and classifying lupus nephritis, use of new therapeutics to obviate the need for steroids in the treatment of ANCA-associated vasculitis, use of machine learning to evaluate subtle changes in imaging in management of inflammatory arthritis, etc.
Nanomedicine for Inflammatory Diseases is a cutting-edge resource for clinicians and scientists alike, working at the intersection of development and clinical therapeutics. This text is ideal for graduate level courses in nanomedicine, translational medicine, or inflammatory disease. This book is a progressive hallmark in translational medicine as it unites clinicians treating inflammatory disease with scientists developing experimental nanomedicine therapeutics. The commonality is made through a translational nanomedicine expert - bridging the gap between the laboratory benchtop and the clinical bedside.
1) General description of the Genetic Polymorphism and its various types 2) Discuss the role of Genetic Polymorphisms in modulating risk of various human diseases 3) Discuss various molecular techniques used for detecting GPs 4) Discuss the role of SNPs in modulating the susceptibility of human diseases 5) Genetic basis for individual variations in response to therapeutics
This book provides an integrative approach for the management and care of the arthritis patient. Many different psychological, social, and behavioral factors have been shown to affect the quality of life of arthritis patients beyond the effects of the disease and the response to medications and treatments. The book establishes a biopsychosocial framework for understanding the interplay between psychological and physical aspects of rheumatic disease and summarizes the research about the psychosocial aspects that affect patients with arthritis, including stress, social support, doctor-patient communication, and sleep patterns. It explores the practice of incorporating psychological and behavioral approaches in the rheumatology clinic in order to surmount the problems of access and enhance the quality of care, promotes a comprehensive perspective on the numerous issues affecting persons with arthritis, and provides clinical guidelines for management. Psychosocial Factors in Arthritis is a valuable resource for behavioral medicine researchers, behavioral clinicians, and a range of arthritis professionals, including rheumatologists, nurses, and other allied health service practitioners.
This book provides up-to-date information on all aspects of the comorbidities that are associated with the headache disorders commonly seen in the primary care and hospital settings, including migraine, tension-type headache, and cluster headache. The coverage is wide ranging and encompasses all of the well-established comorbidities: cardio- and cerebrovascular disease, psychiatric conditions, epilepsy, sleep disorders, and various pain disorders, such as visceral pain, fibromyalgia, orofacial pain, and neuropathic pain. Individual chapters are also devoted to obesity and other metabolic comorbidities and to the comorbidities associated specifically with pediatric headaches. The information provided will assist readers in understanding the complex relationships between headache disorders and these various conditions and in delivering effective care that reflects the latest knowledge. The book is designed to meet the daily practice needs of general physicians, general neurologists, clinical psychologists, neurologists in training, and medical students. It is published as part of the series Headache, which is endorsed by the European Headache Federation - EHF.
This book comprehensively covers the topics and discussions covered at the 10th International Symposium on Nutritional Aspects of Osteoporosis. It is the only international meeting that exclusively covers the role of nutrition on musculoskeletal health and function. Current thinking on the role of nutrition on bone and muscle development and health, and as a means of preventing osteoporosis, falls and fractures is covered. The latest evidence on the potential roles that protein, potassium, B vitamins, vitamin D, omega-3 fatty acids, and flavonoids in the context of bone and muscle health are also discussed. Nutritional Influences on Bone Health reviews the role of nutrition in bone health and its potential role in preventing osteoporosis and sarcopenia in ageing populations, providing a valuable and practically applicable resource for practising and trainee health and medical professionals.
This series provides a clearly structured and comprehensive overview of fracture treatments based on the most recent scientific data. Each book in the series is organized anatomically, so the surgeon can quickly access practical aspects, examples, pearls and pitfalls. In this first volume in the series, fractures of the proximal humerus are examined with an overview of fracture morphology, injury pattern, preoperative considerations, conservative treatment, surgical management and postoperative care. Fractures of the Proximal Humerus is written by a group of experts from the Association for the Rationale Treatment of Fractures (ARTOF) who aim to provide an independent, unbiased summary of fracture treatments to improve clinical outcomes. Trauma and orthopaedic surgeons worldwide who are searching for current knowledge of new implants, therapeutic strategies and advancements will be able to quickly and accurately apply the information from this book to provide the best possible care for their patients.
This book serves as a definitive guide to diagnosing shoulder conditions for all levels of orthopaedic surgeon with an interest in shoulder pathology, and for junior surgeons in training. It comes at a time when the knowledge regarding shoulder conditions has vastly improved, with the shoulder sub-speciality growing at a rapid pace in terms of practitioner numbers, procedures and evidence-base. However, with the multitude of special tests for shoulder conditions, the clinician faces a variety of sensitivities and specificities of the respective tests. It is unclear, in most circumstances, which single test is the best and growing evidence confirms that a set of tests is superior for diagnosing shoulder conditions. This forms the basis of cluster testing, which is the key concept for the title and content of this book. In many common shoulder diagnoses the preference for clusters has been reflected in both experience and clinical evidence, but for conditions where evidence for clusters is less clear, a consensus-based approach is utilised by the authors of this key resource for diagnosing shoulder conditions.
This book covers all aspects of the specialized field of gerontorheumatology, providing a complete overview of rheumatic and musculoskeletal diseases and related conditions in the elderly. The emphasis is particularly on pathogenesis, diagnosis, prevention, and treatment, including the latest advances in biological and pharmacological therapy and potential treatment side effects. The book will provide the reader with a keen awareness of the characteristic features, distinctive etiologies, and different courses of the various disorders of the musculoskeletal system in the geriatric population. Diagnostic and treatment considerations of special relevance in daily practice are highlighted, and the importance of comorbidities and their rheumatic consequences is also emphasized. The book will be of value for gerontologists, rheumatologists, internists, and rehabilitation physicians and will offer excellent guidance for general practitioners, who are typically the first to deal with disorders of the musculoskeletal system in elderly patients.
This book provides a comprehensive review of the recent advances in the research of systemic sclerosis (scleroderma). Systemic sclerosis is a complex autoimmune disease characterized by vasculopathy, fibrosis, and immune activation. This disease is also associated with certain susceptibility genes and is affected by epigenetic regulation. Recent studies have revealed a variety of new evidence suggestive of the pathogenesis of the disease. These include endothelial progenitor cells, cytokines and growth factors, and B cells. Studies using animal models have also provided novel insight into the pathomechanisms. In addition to these topics, the book covers clinical research regarding biomarkers and autoantibodies. This volume will benefit all rheumatologists and dermatologists as well as basic scientists, especially immunologists, molecular biologists, and biochemists.
Nanomedicine for Inflammatory Diseases is a cutting-edge resource for clinicians and scientists alike, working at the intersection of development and clinical therapeutics. This text is ideal for graduate level courses in nanomedicine, translational medicine, or inflammatory disease. This book is a progressive hallmark in translational medicine as it unites clinicians treating inflammatory disease with scientists developing experimental nanomedicine therapeutics. The commonality is made through a translational nanomedicine expert - bridging the gap between the laboratory benchtop and the clinical bedside.
This book focuses on helping both dermatologists and non-dermatologists approach the treatment of each disease in a pragmatic manner. Each chapter reviews the current literature of treatments for each disease, rating disease severity, and provides pragmatic guidelines based on disease severity on the usage of available medications. The current literature does not provide effective guidelines. This book addresses this deficiency. This book will help guide clinicians in implementing appropriate treatments based on the specific disease and its severity, and possible alternatives in an algorithmic format. It will make the management of these diseases more pragmatic based on both the literature and clinical experience of experts. |
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