This issue of Rheumatic Disease Clinics will include articles such as: Vaccines and Biologics- efficacy and toxicity; Improving Vaccine administration in Practice; HCV and rheumatology; HBV reactivation and rheumatic disease; Herpes zoster in rheumatic diseases; Opportunistic infections in biologic therapy, risk and prevention; and many more!

Vasculitis is a term for a group of rare diseases that have in common inflammation of blood vessels and there are many types of vasculitis, and they may vary greatly in symptoms, severity and duration. Vasculitis can range from mild to life-threatening and early detection and treatment of severe vasculitis can prevent permanent damage.

In this first-of-its-kind issue of Rheumatic Disease Clinics, guest editor Dr. Bryant R. England brings his considerable expertise to the topic of Environmental Triggers for Rheumatic Diseases. In practical, state-of-the-art articles, top experts examine the connection between some of the most commonly seen rheumatic disease and environmental triggers for the disease. Contains 13 practice-oriented topics including inhalant and mucosal-related environmental risks for rheumatoid arthritis; lifestyle, hormonal, and microbial-related environmental risks for rheumatoid arthritis; environmental risks for systemic lupus erythematosus; environmental risks for osteoarthritis; targeting environmental risks to prevent rheumatic diseases; and more. Provides in-depth clinical reviews on environmental triggers for rheumatic diseases, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

The prevalence of autoimmune diseases and rheumatic conditions is constantly increasing. Autoimmune diseases affect approximately 7-10% of the population of the United States, while more than 50,000,000 American adults suffer from some type of arthritis. The Heart in Rheumatic, Autoimmune and Inflammatory Diseases examines the complex mechanisms relating to cardiac diseases from a pathophysiological and clinical point of view. Autoimmune rheumatic diseases can affect the coronary vessels, myocardium, pericardium, heart valves and the conduction system. The diagnosis of these unique cardiac complications necessitates medical awareness and a high index of suspicion. Increased risk of advanced atherosclerosis plays a pivotal role in the development of cardiac diseases in systemic, rheumatic and autoimmune illnesses. Yet, other complex immune medicated mechanisms may contribute to the pathogenesis. Patients' optimal care requires coordination between the primary caregiver, the rheumatologist, immunologist and cardiologist. Screening for cardiovascular risk factors, recognition of high-risk patients and identification of subclinical cardiac conditions are of great importance. Moreover, regulation of inflammation, as well as abnormal immune responses and the initiation of early treatments should be the focus of patient management. A continuous attempt to identify novel therapeutic targets and change the natural history of the underlying disease and its cardiac manifestations is in progress. The book aims at providing the readers with a state of the art collection of up to date information regarding clinically important topics based on experts' perspectives. This book was a result of an extended coordinated collaboration of one-hundred and fifty-four distinguished scientists from thirty-one countries around the globe.

In this issue, guest editors bring their considerable expertise to this important topic. Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Antiphospholipid Syndrome in Systemic Autoimmune Diseases, Second Edition provides an overview of our current understanding of this major disease. It includes the latest information on the new pathogenetic mechanisms involved, along with clinical manifestations in both the thrombotic and non-thrombotic manifestations of this important disease. Antiphospholipid syndrome is an autoimmune disease that causes abnormal blood clots. It is now recognized as a major cause of common conditions, including stroke, heart attack, miscarriage, epilepsy, and memory loss, and as such is gaining recognition in all branches of medicine, from obstetrics to cardiology, and from psychiatry to orthopedics.

In this issue of Hand Clinics, guest editors Drs. Phillip Ross and Sarah E. Sasor bring their considerable expertise to the topic of the Thumb CMC Joint. Top experts in the field discuss different strategies for the management of problems with the thumb carpometacarpal (CMC) joint, as well as treatment options. Contains 14 relevant, practice-oriented topics including joint-preserving treatments for thumb CMC osteoarthritis; thumb CMC implant arthroplasty; revision CMC arthroplasty; diagnosis and treatment of CMC instability; and more. Provides in-depth clinical reviews on the thumb CMC joint, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Rheumatic Disease Clinics, guest editor Brian F. Mandell brings his considerable expertise to the topic of Rheumatology pearls for the primary care physician. Provides in-depth reviews on the latest updates in Rheumatology pearls for the primary care physician, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

This issue of Rheumatic Disease Clinics, guest edited by Drs. Laura Schanberg and Yukiko Kimura, will focus on Pediatric Rheumatology. This issue is one of four selected each year by our series Consulting Editor, Dr. Michael Weisman. Part II, also edited by Drs. Kimura and Schanberg, will publish subsequently and cover additional topics relevant for pediatric rheumatologists. Topics discussed in this issue include but are not limited to: TMJ, CNO (CRMO), Update JIA treatment, Pharmacology of biologics in kids, Juvenile Spondylitis, Juvenile fibro update, JDM update, Pediatric Sjogrens, Localized scleroderma, Systemic Sclerosis, Uveitis, COVID-19 in pediatrics, Recent advances in pediatric vasculitis, and Autoinflammatory diseases. Provides in-depth, clinical reviews on the latest updates in Pediatric Rheumatology, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

With guidance from Consulting Editor, Dr. Kevin Loughlin, Dr. Deepak Kapoor has created a state-of-the-art issue devoted to the future of the urologist's clinical practice. Expert authors have contributed clinical review articles on the following topics: Workforce Issues in Urology; Development of Physician Leaders; Physician Burnout; Telemedicine; Understanding the Millenial Physician; The role of APPs in Urology; The impact of private equity transaction on urology; The growth of integrated care models in urology; Current and Future Status of Merit-Based Incentive Payment Systems; Advocacy and Health Policy; How to Subspecialize in Large Group Practices; Drug Prices: Strategies to Help Your Patients Manage the High Cost of Drugs; Operationalizing Clinical Research. Urologists will come away with the information they need to improve their expertise in their urologic practices and to improve patient outcomes.

This book offers an excellent review of the various rheumatological conditions, both common and uncommon, that may present on imaging on a daily basis. The book uses a unique format that will be beneficial for clinicians, radiologists, medical students, and consultant staff. The text is written by both rheumatology and radiology staff to provide a balanced approach. A clinical overview and the common clinical presentations are briefly reviewed for each condition followed by a more detailed discussion of imaging findings produced by the various imaging modalities, including radiographs, ultrasound, MRI, CT, and nuclear medicine. This book details the imaging of normal musculoskeletal anatomy and pathology; discusses image-guided musculoskeletal interventions; and examines disorders such as rheumatoid arthritis, connective tissue disease, osteoarthritis, osteonecrosis, infection-related arthritis, soft tissue calcification, and bone and synovial tumors. Featuring over 600 multi-part, high-resolution images of rheumatic diseases across current imaging modalities, Essential Imaging in Rheumatology offers up-to-date and complete information on the imaging of these disorders. Developed by the authors of Essential Imaging In Rheumatology are three new exciting interactive imaging Apps that enhance the invaluable information provided in the book. Rheumatology and imaging are closely linked specialties particularly with the expansion of the imaging armamentarium available to the rheumatologists in the last decade. Imaging has a strong impact on patient diagnosis, management and outcome, requiring both the rheumatologist and the radiologist to have a clear understanding of pathologies and their variable imaging appearances, differential diagnosis and optimal imaging algorithms. A primary focus of our " Imaging In Rheumatology Edicational Initiative " is to thus to stimulate interest in rheumatological imaging and as such we are delighted to provide a be able to provide our "UnRavelling Spondyloarthropathy" App free. ESIMR: Uncovering The Hand Radiograph iOS https://appsto.re/ca/ydsmfb.i Android https://play.google.com/store/apps/details?id=com.radiologyhand ESIMR: Clinical Case Challenge https://appsto.re/ca/bdsmfb.i https://play.google.com/store/apps/details?id=com.radiologyccc ESIMR: UnRavelling Spondyloarthropathy (Free) https://appsto.re/ca/Tzsmfb.i https://play.google.com/store/apps/details?id=com.radiologyspa

This issue of Rheumatic Disease Clinics, guest edited by Dr. John Davis, will discuss Cancer and Rheumatic Diseases. This issue is one of four selected each year by series Consulting Editor, Dr. Michael Weisman. Topics discussed in this issue include, but are not limited to: rheumatic drugs and malignancy potential, biologic drugs and cancer, methotrexate and cancer, managing rheumatoid arthritis with cancer, Sjogren's Syndrome and cancer, lupus and cancer, scleroderma and cancer, cancer and spondylarthritis, and cancer immunotherapy.

This issue of Rheumatic Disease Clinics, guest edited by Drs. Karina Torralba and James D. Katz, will discuss Education and Professional Development in Rheumatology. This issue is one of four each year selected by our series consulting editor, Dr. Michael Weisman. Articles in this issue include, but are not limited to: From Classroom to Clinic: Clinical Reasoning via Active Learning Strategies; Self-directed Learning of Musculoskeletal Ultrasound for clinicians in practice; Enhancing the inpatient consult service with the Fellow as a Teacher; Translating Quality Improvement in Education to clinical practice; Beyond Class-Rheum: Applying Clinical Epidemiology into Practice; Ethics and Industry Interactions: Impact on Specialty Training, Clinical Practice and Research; Mind the Gap: Improving Care in Pediatric-to-Adult Rheumatology Transitional Clinics; Underserved Communities: Enhancing care with Graduate Medical Education; Turning OSCE into reality; Online Resources for Enhancing Clinical Skills; and Addressing Health Disparities in Medical Education and Clinical Practice.

Guest edited by Drs. Jonathan Kay and Sergio Schwartzman, this issue of Rheumatic Disease Clinics will cover Controversies in Rheumatology. This issue is one of four selected each year by our series Consulting Editor, Dr. Michael Weisman of Cedars-Sinai. Articles explore several questions, including, but not limited to: Is triple therapy or methotrexate plus a biologic the initial treatment of choice for RA patients; Is hypo or hyper-uricemia a risk requiring treatment for cardiac morbidity and mortality; Are there benefits and risks to biosimilars from a patient perspective; Should platelet-rich plasma be used to treat osteoarthritis; Is there a role for stem cell therapy to treat cartilage defects in osteoarthritis; Should any rheumatology patient, today, be treated with bone marrow ablation and stem cell transplantation; Is there effective prevention, prophylaxis, or treatment for CPPD arthritis; Is fibromyalgia a psychiatric disease or a pain syndrome; Should cyclophosphamide still be used to treat ANCA-associated vasculitis; Does methotrexate have a place in the treatment of psoriatic arthritis; Should hydroxychloroquine dosing be limited because of potential ocular toxicity; and Should generalized immunosuppression or targeted organ treatment be the best principle for overall management of SLE.

Guest edited by Drs. Jeffrey Curtis, Kevin Winthrop and Kaleb Michaud, this issue of Rheumatic Disease Clinics will cover several key areas of interest related to Technology and Big Data in Rheumatology. This issue is one of four selected each year by our series Consulting Editor, Dr. Michael Weisman of Cedars-Sinai. Articles in this issue include, but are not limited to: Adherence & Adverse Event Ascertainment through mHealth; Digital Patient Education and Decision Aids; Imaging in the mobile domain; Quality Measures made easier with mHealth data; Patient self-management and tracking; Motivational Counseling and SMS Reminders; Digital Interventions to build community support; Telehealth to solve cases in under-resourced areas; Trials, eConsents, Data Linkage & the Future; Clinical experience with devices; and PROMIS vs legacy data instruments.

As many as fifteen million American women, or 5 percent of the adult female population in the US, suffer from the disabling medical condition known as fibromyalgia. If one takes into account husbands, partners, children, and other close relatives, the proportion of the American population directly or indirectly affected by fibromyalgia could be as high as 10 percent, or thirty million persons.
Nonetheless, the medical community is divided over the reality of this condition. One side argues, sometimes heatedly, that the patients are masquerading - pretending a disability they know they do not have. The other side counters, with equal passion, that fibromyalgia sufferers are abused by a society that fails to give them the support they deserve while painfully suffering from this severely debilitating illness.
Without taking sides, Dr. M. Clement Hall presents six fictional, though factually based, case studies of typical patients from differing socioeconomic backgrounds and describes the varying investigations, diagnoses, and treatments they have undergone. Each of these case studies represents a composite of many years of clinical practice rather than one specific patient. Collectively, they cover the range of experiences fibromyalgia patients are likely to have encountered.
By taking this unique approach, Dr. Hall presents an objective overview of the fibromyalgia situation today in North America. Patients, family members, and physicians will see themselves reflected in the descriptions and will gain a broader understanding of this challenging illness.

This issue of Rheumatic Disease Clinics, guest edited by Drs. Andrew Bomback and Meghan Sise, will cover several key aspects of Renal Involvement in Rheumatic Diseases. The Consulting Editor for the series is Dr. Michael Weisman. The topics discussed in the issue will include: ANCA, Lupus GN, proliferative and non-proliferative, Renal manifestations of RA, Secondary amyloidosis, Nephrotoxicity of select rheumatology drugs, Acute and chronic TI nephritis, rheumatology etiologies, TMAs with rheum etiologies, Anti-GBM, Autoimmune manifestations of viral infections, and Renal manifestations of IBD, among others.

This issue of Rheumatic Disease Clinics, guest edited by Dr. Sindhu Johnson, will cover Advances in Epidemiologic Methods to Study Rheumatic Diseases. This unique volume will discuss the following topics, among others: Minimal clinically important difference (MCID) for outcome measures, Alternative longitudinal study designs, Propensity score methods for observational data, Approaches to deal with missing data, Applied Bayesian Methods in Rheumatology, Qualitative methods, Similarity Network Fusion, Systematic reviews/meta-analysis and randomized trials, and Integrated analysis of data obtained in various reading campaigns of images.

This issue of Rheumatic Disease Clinics, guest edited by Drs. James Katz and Brian Walitt with the NIH, will cover several key aspects of diagnosing and treating Rheumatic Diseases in Older Adults. The Consulting Editor for the series is Dr. Michael Weisman. The topics discussed in the issue will include: Pharmacotherapy Pearls for the Geriatrician, Pathogenesis and Management of Sarcopenia, A Review of Osteoporosis in the Older Adult, Regional Rheumatic Disorders and Rehabilitation in Older Adults, Rheumatologic Manifestations of Malignancy, Sjoegren Syndrome and Other Causes of Sicca in Older Adults, Cardiovascular Disease Risk in Patients with Rheumatic Diseases, Update on Crystal-Induced Arthritides, Immune dysregulation in aging with a focus on B cells and their potential clinical consequence, and Spinal Stenosis, among others.