This important book fills a need in the developing area of Pain Medicine. It provides physicians with an up-to-date resource that details the current understanding about the basic science underlying the mechanism of action of the various CAM therapies used for pain. It summarizes the clinical evidence both for efficacy and safety, and finishes with practical guidelines about how such treatments could be successfully and safely integrated into a Pain practice.

Commissioned by the Swiss Federation of Manual Medicine and under the patronage of FIMM (International Federation of Manual Medicine) we conducted an international seminar during the week following the 7th Inter national Congress of FIMM (Zuerich/Switzerland - September 1983). Thirty Manual Medicine experts had come together in the education center of the Cloister Fischingen secluded in the eastern part of Switzerland and away from any city life, to discuss in a week long seminar the status of Man ual Medicine. Working together in the form of several groups, the following points were emphasized: - terminology - diagnostic criteria (are Manual Medicine findings reproducible?) - therapeutic interventions (degree of congruity of treatment plans) The participants demonstrated great enthusiasm and commitment, and so it was possible to have the content of the individual group's discussion com municated to and presented for further scrutiny to all participants during the seminar week. As members of the organizing committee and as the editors of this publica tion, we hope to help establish a more standardized international terminolo gy concerning the field of Manual Medicine. As this clinical trial (investigating the diagnostic reliability and the therapeu tic efficiency of MM) shows, factors such as terminology, diagnostic criteria and therapeutic plans are a prerequisite for multi-center studies.

It is with great pleasure that I write this Foreword to the Proceedings of the International Conference on Behcet's Disease which was held in Berlin in June 2002. This was the first International Conference held under the auspices of the International Society for Behcet's Disease which was founded in 2000 in Seoul. First, I congratulate our colleagues in Berlin, led by Professor Christos Zouboulis of the Department of Dermatology at the Free University of Berlin, for having organised a most successful conference and for having compiled these proceedings so rapidly. It will be realised immediately on scanning the contents of this book that the conference was truly international with 210 participants from 26 countries, as Professor Zouboulis has noted in his preface. These included basic scientists, epidemiologists, pathologists, clinicians and, importantly, representatives from patient organisations. The latter held their own conference alongside the scientific-medical conference to mutual benefit. The combined session of patients and doctors (abstracts on pp 601 - 626) gave the opportunity for an exchange of information and fruitful discussion. The wide ranging scope of the communications is evident from the index and it was most encouraging to see their origin - from all parts of the world, from senior and junior colleagues and, from many different disciplines. Many communications may be regarded as preliminary reports of research in progress and we look forward to seeing the definitive publications in appropriate journals in due course."

Mechanisms of Lymphocyte Activation and Immune Regulation X Innate Immunity is the proceedings of the Xth International Conference on Mechanisms of Lymphocyte Activation and Immune Regulation: Innate Immunity, held February 6-8, 2004 in Newport Beach, California. It is the tenth volume of its kind to appear in the series Advances in Experimental Medicine and Biology. Topics include toll receptors, dendritic cells, NK cells, and complement receptors.

Any physician travelling to other centres throughout the world must be struck by the similarity of the problems in diagnosis and management faced by fellow colleagues in rheumatology. Despite the international spread of journals and of standard textbooks, the same practical questions constantly appear - how do you manage the psychotic patient with cerebral lupus, or the patient with intractable polymyositis, or the rheumatoid patient who has failed on almost all known therapeutic agents. Is it worth differentiating various 'overlap' syndromes? How can one improve on the classification and treatment "i}f.vasculitis? Two questions - what is the patient telling us? and what can we do for the patient? are always central to the discussion. Although these high-minded ideals are often not fulfilled, frequently something new appears to come from individual case presentations. These cases, discussed at our weekly conferences, were contributed by a number of different staff members. Where possible, a standard format has been use in each case presentation and a comment added where indicated. A short list of relevant references has been included with each case. The aim of this book is to provide examples of these clinical problems and our own clinical approach to them - sometimes successfu~ sometimes not.

George Tsokos and a panel of authoritative clinicians and researchers synthesize the latest findings from across cell and molecular biology with the basic principles of rheumatology to create the first textbook of molecular rheumatology. These established experts describe the biochemical mechanisms by which apoptosis, cell signaling, complement, lipids, and viruses contribute to disease expression, and detail both immune and nonimmune cell function in rheumatic diseases. Their review of the major rheumatic diseases integrates the cellular, biochemical, and molecular biological mechanisms that are important in rheumatic disease pathogenesis. Path-breaking and illuminating, Principles of Molecular Rheumatology expands the envelope of clinical understanding to reveal the biological roots underlying rheumatologic disease, as well as the nature and roles of the powerful new therapeutics now emerging for its optimal treatment.

Azapropazone is a chemically unique non-steroidal anti-inflammatory drug (benzotriazine oxide) which has found successful clinical applications in the therapy of a wide variety of arthritic conditions. This book summarizes the progress and critically reviews the clinical use and experimental studies since its introduction 20 years ago. Several studies focus on the physiochemical, pharmacological and toxico logical properties of this drug. The studies suggest that it has some unique properties compared with other non-steroidal anti-inflammatory drugs. Among these the novel observations are that azapropazone inhibits several non-prostaglandin-related leucocyte functions, especially superoxide anion production. These serve as a basis for investigations which are reviewed showing the potential for the drug to prevent the pathological consequencies of myocardial ischaemia. The preparation of this book would not have been possible without the cooperation of the four companies who produce, market, or have research involvement with azapropazone, namely Siegfried AG (the manufacturers of the drug), A.H. Robins (U.K.) Co. Ltd., Robapharm AG (Switzerland) and E. . duPont de Nemours (U.S.A., Switzerland and F.R.G.)."

Although dermatomyositis is a rare connective tissue disease, many physicians are confronted with the diagnosis and treatment of patients affected by this condition. Based on the vast personal experience of the authors, who have diagnosed, treated, and managed many dermatomyositis patients, this clinical guide provides dermatologists, rheumatologists, pediatricians, neurologists, and general practitioners with the keys to interpreting the clinical symptoms of dermatomyositis. Also included are algorithms to help the reader to make the correct diagnosis, as well as guidance on new diagnostic methods and treatment schemes.

Rheumatology: Symptoms and Syndromes organizes the rheumatic diseases in the form of syndromes as stable combinations of symptoms, and links these to morphological manifestations. This presentation of the rheumatic diseases provides a pedagogical framework for differential diagnosis in rheumatology. To further aid the teacher and student, Professor Efim Benenson provides algorithms of clinical reasoning based on morphology and pathophysiology. Professor Benenson's practice-oriented, didactic approach, and innovative organization of the rheumatic diseases is a valuable diagnostic aid to practicing rheumatologists and those teaching or training in rheumatology.

Readers are recommended the companion book, Rheumatology: Clinical Scenarios, for further reading on Professor Benensons's organization of the rheumatic diseases.

Cervical Spine Research Society European Branch "The Cervical Spine Research Society is an organization of individuals interested in clinical and research problems of the cervical spine. Its purpose is for the exchange and development of ideas and philosophy regarding the diagnosis and treatment of cervical spine injury and disease. The com position of the membership should reflect the varying specialities and disciplines dealing with the cervical spine; biochemical, engineering, neurology, neurosurgery, radiology, orthopedic surgery and others," wrote J. William Fielding, New York City, one of the Society'S founding members. In 1984 the membership list contained 118 names. The overwhelming majority of members came from the United States, four from Canada and 9 Europeans, amongst them Mario Boni. He was the organizer, in con junction with the members of the Cervical Spine Research Society, of a splendid "International Meeting for the updating on pathology and surgery Preface VI of the cervical spine" held in Pavia (Italy) in May 1982. It was from this meeting that the idea of a European branch of the Society first originated, with the purpose of establishing multi-disciplinary meetings in Europe. The first meeting of the European branch was organized by A. Weidner in September 1984 in Osnabriick (Federal Republic of Germany). Mario Boni was elected president. He was not only the initiator but also the drivinglorce who tirelessly promoted the development of the European branch. Mario Boni's death in 1986 at the age of 64 was a great loss to us."

There is currently no single book with up to date information on osteoclast function and bone resorption.

A useful collection of information, not readily available in a concentrated and convenient form on the market.

Provides a comprehensive overview of the field.

Bone research in recent years has generated much new knowledge, in large measure because of the broad public health implications of osteoporosis and related bone disorders. Bone Formation, the first in a series entitled Topics in Bone Biology, evaluates this new information and formulates novel insights and hypotheses within the broad framework of current knowledge. An easy-to handle and to read work, with concise reviews that are extensively referenced, the chapters in this book are written by internationally known authorities. Particular emphasis is on osteoporosis and related disorders of diminished bone formation. Among the general topics treated is a chapter on biomechanical aspects of bone formation, not often considered in relation to diseases of bone formation. The book constitutes essential reading for those entering the field of bone biology and those who wish to become familiar with up-to-date information in a particular area of bone research.

Edited by two leading orthopedic surgeons who are specialists in the treatment of hemophilia, Orthopedic Surgery in Patients with Hemophilia shows all the surgical techniques needed for surgical treatment of musculoskeletal complications of hemophilia. A practical guide, designed for use on the ward or in the office, this book draws on the experience of numerous specialists worldwide, from developed and developing countries. As well as orthopedic surgery, it also covers research, hematology, and rehabilitation. Although of primary interest to the orthopedic surgeon, rheumatologist, and physiotherapist, this book will also be relevant to the hematologist responsible for the care of the hemophiliac patient.

Plain radiography is still alive. In many institutions, including ours, conventional radiography has been replaced by digital systems including imaging-plate-based computed radiography and fat-panel detector-based digital radiography. Even for the education of radiation technologists, conventional flm-screen radiography has been de-- phasized, and their education is concentrated on digital systems. Spatial resolution of a conventional system is still far better than the current digital systems, although the dynamic range is wider in the latter system. Industrial flm radiography with small grain size and direct exposure has an even higher resolution, and such hi- resolution systems are something we lost in the transition from the conventional system to the current PACS-friendly system. I am pleased to know that Giuseppe Guglielmi and Wilfred Peh have published this textbook of high-resolution hand radiographs that cannot be obtained with any other techniques. Radiography has always been the most important modality in the evaluation of the hand, and, moreover, high-resolution industrial flms are extremely efective in the evaluation of the hand, particularly for assessing subtle erosions. Hands are not just one of the peripheries of the human body. Tey refect conditions of the whole human body. Not only the metabolic status, but also many congenital disorders are manifested in the hand. Radiographic fndings of the hand are ofen specifc, and contribute to the diagnoses a great deal. Tere have been several publications concerning the radiology of the hand, and they have been well accepted.

Sine syndromes (SSs) represent atypical forms of inflammatory rheumatic diseases, the courses of which are often severe. While the diagnosis of rheumatic diseases can be determined according to an established set of diagnostic criteria based on clinical characteristics and laboratory parameters, Sine Syndromes do not fulfill the standard criteria used to assist in the classification of patients with rheumatological disorders. This concise book gives an overview of atypical courses in common inflammatory rheumatic diseases such as Wegener's granulomatosis, systemic sclerosis, Sjoegren's syndrome, or systemic lupus erythematosus. Each chapter reviews similar cases reported in the literature and presents current data on treatment options. Drawing on their vast clinical experience, the editors provide a series of detailed case reports in order to illustrate the different types of disease. The book is intended to facilitate early diagnosis and effective therapy in patients where a schematic approach may not prove sufficient. Sine Syndromes in Rheumatology will serve as a useful and easily accessible reference for specialists in rheumatology as well as for practitioners in the fields of internal medicine, pediatrics, and orthopedics.

Back in September of 1974, I acquired much valuable information while attending the International Conference on Total Knee Replacement in London, which was organized by The Medical Engineering Working Party and the Tribology Group of the Institution of Mechanical Engineers, and the British Orthopaedic Association. I was greatly inspired by the conference, and it formed the beginning of my studies on total knee replacement. The co-editors of this proceedings, Prof. J. Paul and Dr. S. Yamamoto, are both acquaintances made originally at that conference. The International Symposium on Total Knee Replacement held in Nagoya, Japan, on 18-19 May 1987 was attended by many participants, including Prof. Walker, who had presented his studies earlier in London. During the past decade and a half, remarkable technical progress has been made in total knee prostheses. In this symposium, cemented total knee replacement (TKR), noncemented TKR, design considerations of total knee prostheses, problems concerning the patello femoral joint, and the newly developed total knee prosthesis were the main topics discussed. I believe that much new information, including that about the challenges which still remain, along with a fresh view towards continuing studies, are presented here for the reader. I would like to express my sincere gratitude to the support of the Knee Joint Research Society in Japan and to the participants in the symposium for their great help in publishing this book."

Written by a world-renowned expert in rheumatology this book serves as a refresher for GPs and hospital doctors containing practical diagnostic and treatment advice.

Reviews clinical developments and guidelines, and places them into everyday clinical practice

Stresses the importance of early and aggressive treatment

Concise but comprehensive whilst being loaded with illustrations including imaging examples all presented in pocket sized format

Rheumatoid arthritis (RA) is the most common and serious inflammatory arthritis, resulting in joint destruction, functional impairment and increased mortality. The outcome of the disease, however, has improved considerably in recent years with the availability of effective therapies and the recognition that early intensive treatment strategies result in better outcomes.

This book has been designed to increase physician awareness of the importance of early and intensive treatment a key pharmaceutical strategy in rheumatoid arthritis.

Rheumatology of the Upper Limbs in Clinical Practice is a comprehensive and easy-to-use training tool for practitioners to refine their strategy for clinical investigation and differential diagnosis in regional syndromes of the shoulder, elbow, forearm, wrist and hand. It combines instructive sections, providing anatomical information and various causes of particular symptoms. Case studies recreate the clinical setting by presenting the details of the case and giving an opportunity for the reader to make a diagnosis. The text is lavishly illustrated in full color, with detailed photos of patient examinations, complemented by radiographs and full color line illustrations. The text also benefits from the use of summaries using colored boxing to identify key points in diagnosis and management. Written by two of the biggest and most respected clinicians in the discipline, this book will be essential reading for rheumatologists in practice and training.

A definitive review in the field of magnesium research, this book brings together the proceedings of the 11th International Magnesium Symposium in Osaka, Japan from October 22-26, 2006. Written by authorities in the area, the book provides a thorough overview of progress in the area of magnesium research. The author is one of the world's foremost magnesium researchers and reviewers, and the book provides essential reading for researchers in magnesium.

At present we may be at the cross-roads in the therapeutic approaches we have for the treatment of the 100 or more rheumatic conditions. This is be cause we now recognise that although some advances have been made with the development of a large range of non-steroidal and steroidal drugs during the past two decades or so, we now recognise that many, if not all, of these have rather limited effects on many of the disease processes which underlie the manifestations of the various rheumatic states. Advances in molecular bi- 010gy in the past 5-10 years have enabled these tools to be applied extensive ly for developing further our understanding of the rheumatic disease processes. In some cases these molecular tools (e. g., ), -interferon, interleukin- 2, T-cell antibodies) have been directly employed as therapies themselves. While the outcome from trials with such agents in rheumatoid arthritis in particular has not been as would have been hoped, these results as with cy closporin A and low-dose methotrexate in the therapy of rheumatoid arth ritis have given us important indications for the approach employing what are generally described as "immunomodulators" to control this disease. But this may not be the same type of approach which is desirable for all types of rheumatic conditions. Indeed, even the way which the present range of drugs and other therapies are applied may not be the most effective and safe means of treating different types of arthritic conditions."

A new edition of an established research-based text on one of the fastest growing topics in nursing: nurses dealing with this complex subject need to be kept up to date and this book written by a team of expert rheumatology nurses fills that role.

The book's emphasis is on addressing the patients' problems, assessing the effects of the disease both on the body and psychologically and suggesting treatments best suited to the individual patient. It encourages nurses to work in partnership with the patients and their carers, adopting a holistic approach to care.Edited by an acknowledged international expert in the development of the specialtyCovers the needs of all nurses involved with rheumatology patients both in hospital and at homeResearch-based and completely updated to include the latest developments in treatments available

Pathology and Pathobiology of Rheumatic Diseases glows with the uncommon precision of the pathologist, the clarity of the tea cher, and the unswerving commitment of the investigator. Fass bender has produced a major contribution to the literature of rheumatic diseases. The practical experience and wisdom brought together in this book, substantiated by excellent exam ples of histopathology, produce a landmark for all who have made the study of rheumatic diseases their profession. The enor mous achievements made in molecular biology, genetics, struc tural biochemistry, and clinical science have been assembled in this book to interact in a meaningful way with the anatomical histology of the rheumatic diseases. It is not easy for any single investigator to paint the picture of a disease process, from its clinical description to its mechanisms, and then to a defined hypothesis, and finally an understanding. Nonetheless, Fassbender has done this in a clear and convincing way that integrates our current knowledge of this group of dis eases. Scientific discovery in medicine moves from the bedside to the bench, back to the bedside, and then back to the bench, etc. It is this iterative process of new observation and new discovery that has given us the achievements in medicine over the past century."

Over the past decade, major advances have taken place in the management of osteoporosis. Newdasses of pharmaceutical agents have been developed, tested, and used to treat millions of patients; education and early detection programs have been instituted around the world; and bone densitometry has received widespread recognition by healthcare agencies as being central to the preven tive health strategy necessary to care for an aging population. With all these advances, scientists continue to explore new methods to understand and treat this disease. The field of orthopaedic surgery has a great opportunity to bring this new information to its dinics and operating rooms. It is critically impor tant that the practicing surgeon be armed with this knowledge. Fractures are dearly the most common orthopaedic problem associated with osteoporosis. The goals of treatment are rapid restoration of mobilityand func tion and return of patients to a level of activity that supports their general health. The ability to control the metabolic condition or to treat the under lying cause of the osteoporosis with pharmacological intervention willimprove surgical results. Moreover, the special techniques required to succeed in the operative treatment of bone, which is already weakened by osteoporosis, must be carefully developed, tested, and understood. This book provides the first attempt to bring this body of information to the orthopaedic surgeon in a dearly organized and comprehensive way. Historically, few orthopaedic surgery or trauma training programs have offered much in the way of education in the science of bone metabolism."

The third edition of this book has been comprehensively rewritten and rearranged. In addition to the bone and joint diseases described in the two earlier editions, it now encompasses hitherto unpublished novel applications of pinhole scanning to the diagnosis of a broader spectrum of skeletal disorders. The book has been considerably expanded to discuss five new themes and is complemented by the addition of some 90 recently acquired cases.

The book summarizes recent advances in the elucidation of the mechanisms involved in senile osteoporosis as well as its potential treatment, bringing an integrated approach from the bench to the clinical practice. A unique aspect of this book is its emphasis on the application of translational research in the field of osteoporosis and falls. The book provides a complete review on the prevention as well as current and future treatments of osteoporosis.