Sine syndromes (SSs) represent atypical forms of inflammatory rheumatic diseases, the courses of which are often severe. While the diagnosis of rheumatic diseases can be determined according to an established set of diagnostic criteria based on clinical characteristics and laboratory parameters, Sine Syndromes do not fulfill the standard criteria used to assist in the classification of patients with rheumatological disorders. This concise book gives an overview of atypical courses in common inflammatory rheumatic diseases such as Wegener's granulomatosis, systemic sclerosis, Sjoegren's syndrome, or systemic lupus erythematosus. Each chapter reviews similar cases reported in the literature and presents current data on treatment options. Drawing on their vast clinical experience, the editors provide a series of detailed case reports in order to illustrate the different types of disease. The book is intended to facilitate early diagnosis and effective therapy in patients where a schematic approach may not prove sufficient. Sine Syndromes in Rheumatology will serve as a useful and easily accessible reference for specialists in rheumatology as well as for practitioners in the fields of internal medicine, pediatrics, and orthopedics.

At present we may be at the cross-roads in the therapeutic approaches we have for the treatment of the 100 or more rheumatic conditions. This is be cause we now recognise that although some advances have been made with the development of a large range of non-steroidal and steroidal drugs during the past two decades or so, we now recognise that many, if not all, of these have rather limited effects on many of the disease processes which underlie the manifestations of the various rheumatic states. Advances in molecular bi- 010gy in the past 5-10 years have enabled these tools to be applied extensive ly for developing further our understanding of the rheumatic disease processes. In some cases these molecular tools (e. g., ), -interferon, interleukin- 2, T-cell antibodies) have been directly employed as therapies themselves. While the outcome from trials with such agents in rheumatoid arthritis in particular has not been as would have been hoped, these results as with cy closporin A and low-dose methotrexate in the therapy of rheumatoid arth ritis have given us important indications for the approach employing what are generally described as "immunomodulators" to control this disease. But this may not be the same type of approach which is desirable for all types of rheumatic conditions. Indeed, even the way which the present range of drugs and other therapies are applied may not be the most effective and safe means of treating different types of arthritic conditions."

Any physician travelling to other centres throughout the world must be struck by the similarity of the problems in diagnosis and management faced by fellow colleagues in rheumatology. Despite the international spread of journals and of standard textbooks, the same practical questions constantly appear - how do you manage the psychotic patient with cerebral lupus, or the patient with intractable polymyositis, or the rheumatoid patient who has failed on almost all known therapeutic agents. Is it worth differentiating various 'overlap' syndromes? How can one improve on the classification and treatment "i}f.vasculitis? Two questions - what is the patient telling us? and what can we do for the patient? are always central to the discussion. Although these high-minded ideals are often not fulfilled, frequently something new appears to come from individual case presentations. These cases, discussed at our weekly conferences, were contributed by a number of different staff members. Where possible, a standard format has been use in each case presentation and a comment added where indicated. A short list of relevant references has been included with each case. The aim of this book is to provide examples of these clinical problems and our own clinical approach to them - sometimes successfu~ sometimes not.

Ankylosing spondylitis (AS), currently grouped under the term axial spondyloarthritis (axSpA), is a chronic form of arthritis that causes inflammatory back pain and can gradually result in impaired spinal mobility. It can also cause eye inflammation (uveitis), arthritis of limb joints, inflammation at sites of bony attachments of tendons and ligaments (enthesitis), and associated psoriasis and inflammatory bowel disease. No cure has yet been found; however, early diagnosis and proper medical and lifestyle management are very important in reducing the risk of deformity and disability. Written by a leading expert on the subject who himself has been living with AS since age 12, this book provides clear and practical information on the clinical symptoms and signs, underlying causes, genetic predisposition, diagnosis, treatments, and impact on daily life. The combination of scientific knowledge and personal experience results in a unique book which will prove invaluable for patients and their families and friends, as well as allied health professionals and students wishing to know more about the condition. The second edition has been fully updated to cover the tremendous advancements made in the clinical recognition and effective management since the first edition in 2002. It also includes a glossary of medical terms and links to sources of further information to give patients the tools they need to understand and manage the condition effectively.

During the past decade there has been a burgeoning of interest in arthritis and related rheumatic diseases. The spe ciality of rheumatology, once regarded as a "Cinderella" speciality, is now one of the leading specialties in internal medicine. Indeed, just as infant mortality is a good index of the general health of a community, so a University Med ical School can be similarly judged by the quality of its Department of Rheumatology. Perhaps no other specialty has helped to advance knowledge in medicine as has rheu matology One might have thought that little could be added to the clinical and radiologic description of one of the most studied diseases in rheumatology rheumatoid arthritis. There are several excellent large radiology textbooks on bones and joints, and it is surprising that yet another book has been published. However, the reader will soon appreciate on reading this superb radiologic text on rheumatoid arthritis that here is something new and quite different from what has been published in the past. The combination of clinician and radiologist has produced a textbook which will become a standard reference on the subject. The authors are both well known in their respective fields and they have concentrated on the early changes in the disease-not only those in the articular surfaces but also those in the soft tissues. In 1948 the late Dr Philip Ellman coined the term "rheumatoid disease," to indicate the systemic nature of rheumatoid arthritis."

This important book fills a need in the developing area of Pain Medicine. It provides physicians with an up-to-date resource that details the current understanding about the basic science underlying the mechanism of action of the various CAM therapies used for pain. It summarizes the clinical evidence both for efficacy and safety, and finishes with practical guidelines about how such treatments could be successfully and safely integrated into a Pain practice.

It is with great pleasure that I write this Foreword to the Proceedings of the International Conference on Behcet's Disease which was held in Berlin in June 2002. This was the first International Conference held under the auspices of the International Society for Behcet's Disease which was founded in 2000 in Seoul. First, I congratulate our colleagues in Berlin, led by Professor Christos Zouboulis of the Department of Dermatology at the Free University of Berlin, for having organised a most successful conference and for having compiled these proceedings so rapidly. It will be realised immediately on scanning the contents of this book that the conference was truly international with 210 participants from 26 countries, as Professor Zouboulis has noted in his preface. These included basic scientists, epidemiologists, pathologists, clinicians and, importantly, representatives from patient organisations. The latter held their own conference alongside the scientific-medical conference to mutual benefit. The combined session of patients and doctors (abstracts on pp 601 - 626) gave the opportunity for an exchange of information and fruitful discussion. The wide ranging scope of the communications is evident from the index and it was most encouraging to see their origin - from all parts of the world, from senior and junior colleagues and, from many different disciplines. Many communications may be regarded as preliminary reports of research in progress and we look forward to seeing the definitive publications in appropriate journals in due course."

Mechanisms of Lymphocyte Activation and Immune Regulation X Innate Immunity is the proceedings of the Xth International Conference on Mechanisms of Lymphocyte Activation and Immune Regulation: Innate Immunity, held February 6-8, 2004 in Newport Beach, California. It is the tenth volume of its kind to appear in the series Advances in Experimental Medicine and Biology. Topics include toll receptors, dendritic cells, NK cells, and complement receptors.

Pathology and Pathobiology of Rheumatic Diseases glows with the uncommon precision of the pathologist, the clarity of the tea cher, and the unswerving commitment of the investigator. Fass bender has produced a major contribution to the literature of rheumatic diseases. The practical experience and wisdom brought together in this book, substantiated by excellent exam ples of histopathology, produce a landmark for all who have made the study of rheumatic diseases their profession. The enor mous achievements made in molecular biology, genetics, struc tural biochemistry, and clinical science have been assembled in this book to interact in a meaningful way with the anatomical histology of the rheumatic diseases. It is not easy for any single investigator to paint the picture of a disease process, from its clinical description to its mechanisms, and then to a defined hypothesis, and finally an understanding. Nonetheless, Fassbender has done this in a clear and convincing way that integrates our current knowledge of this group of dis eases. Scientific discovery in medicine moves from the bedside to the bench, back to the bedside, and then back to the bench, etc. It is this iterative process of new observation and new discovery that has given us the achievements in medicine over the past century."

George Tsokos and a panel of authoritative clinicians and researchers synthesize the latest findings from across cell and molecular biology with the basic principles of rheumatology to create the first textbook of molecular rheumatology. These established experts describe the biochemical mechanisms by which apoptosis, cell signaling, complement, lipids, and viruses contribute to disease expression, and detail both immune and nonimmune cell function in rheumatic diseases. Their review of the major rheumatic diseases integrates the cellular, biochemical, and molecular biological mechanisms that are important in rheumatic disease pathogenesis. Path-breaking and illuminating, Principles of Molecular Rheumatology expands the envelope of clinical understanding to reveal the biological roots underlying rheumatologic disease, as well as the nature and roles of the powerful new therapeutics now emerging for its optimal treatment.

Although dermatomyositis is a rare connective tissue disease, many physicians are confronted with the diagnosis and treatment of patients affected by this condition. Based on the vast personal experience of the authors, who have diagnosed, treated, and managed many dermatomyositis patients, this clinical guide provides dermatologists, rheumatologists, pediatricians, neurologists, and general practitioners with the keys to interpreting the clinical symptoms of dermatomyositis. Also included are algorithms to help the reader to make the correct diagnosis, as well as guidance on new diagnostic methods and treatment schemes.

Rheumatology: Symptoms and Syndromes organizes the rheumatic diseases in the form of syndromes as stable combinations of symptoms, and links these to morphological manifestations. This presentation of the rheumatic diseases provides a pedagogical framework for differential diagnosis in rheumatology. To further aid the teacher and student, Professor Efim Benenson provides algorithms of clinical reasoning based on morphology and pathophysiology. Professor Benenson's practice-oriented, didactic approach, and innovative organization of the rheumatic diseases is a valuable diagnostic aid to practicing rheumatologists and those teaching or training in rheumatology.

Readers are recommended the companion book, Rheumatology: Clinical Scenarios, for further reading on Professor Benensons's organization of the rheumatic diseases.

Bone research in recent years has generated much new knowledge, in large measure because of the broad public health implications of osteoporosis and related bone disorders. Bone Formation, the first in a series entitled Topics in Bone Biology, evaluates this new information and formulates novel insights and hypotheses within the broad framework of current knowledge. An easy-to handle and to read work, with concise reviews that are extensively referenced, the chapters in this book are written by internationally known authorities. Particular emphasis is on osteoporosis and related disorders of diminished bone formation. Among the general topics treated is a chapter on biomechanical aspects of bone formation, not often considered in relation to diseases of bone formation. The book constitutes essential reading for those entering the field of bone biology and those who wish to become familiar with up-to-date information in a particular area of bone research.

There is currently no single book with up to date information on osteoclast function and bone resorption.

A useful collection of information, not readily available in a concentrated and convenient form on the market.

Provides a comprehensive overview of the field.

Edited by two leading orthopedic surgeons who are specialists in the treatment of hemophilia, Orthopedic Surgery in Patients with Hemophilia shows all the surgical techniques needed for surgical treatment of musculoskeletal complications of hemophilia. A practical guide, designed for use on the ward or in the office, this book draws on the experience of numerous specialists worldwide, from developed and developing countries. As well as orthopedic surgery, it also covers research, hematology, and rehabilitation. Although of primary interest to the orthopedic surgeon, rheumatologist, and physiotherapist, this book will also be relevant to the hematologist responsible for the care of the hemophiliac patient.

The third edition of this book has been comprehensively rewritten and rearranged. In addition to the bone and joint diseases described in the two earlier editions, it now encompasses hitherto unpublished novel applications of pinhole scanning to the diagnosis of a broader spectrum of skeletal disorders. The book has been considerably expanded to discuss five new themes and is complemented by the addition of some 90 recently acquired cases.

The molecular and cellular approaches to the relationship of joint and bone problems distinguish this from other books on the topic. Advances in bone and joint biology enable practitioners to approach clinical problems more comprehensively. Emphasis on genetics and on newer viewpoints and approaches, exemplified by the possible effect of subchondral bone on osteoarthritis, gives a wider viewpoint to the reader and may enable novel approaches to solving a clinical problem.

Plain radiography is still alive. In many institutions, including ours, conventional radiography has been replaced by digital systems including imaging-plate-based computed radiography and fat-panel detector-based digital radiography. Even for the education of radiation technologists, conventional flm-screen radiography has been de-- phasized, and their education is concentrated on digital systems. Spatial resolution of a conventional system is still far better than the current digital systems, although the dynamic range is wider in the latter system. Industrial flm radiography with small grain size and direct exposure has an even higher resolution, and such hi- resolution systems are something we lost in the transition from the conventional system to the current PACS-friendly system. I am pleased to know that Giuseppe Guglielmi and Wilfred Peh have published this textbook of high-resolution hand radiographs that cannot be obtained with any other techniques. Radiography has always been the most important modality in the evaluation of the hand, and, moreover, high-resolution industrial flms are extremely efective in the evaluation of the hand, particularly for assessing subtle erosions. Hands are not just one of the peripheries of the human body. Tey refect conditions of the whole human body. Not only the metabolic status, but also many congenital disorders are manifested in the hand. Radiographic fndings of the hand are ofen specifc, and contribute to the diagnoses a great deal. Tere have been several publications concerning the radiology of the hand, and they have been well accepted.

A definitive review in the field of magnesium research, this book brings together the proceedings of the 11th International Magnesium Symposium in Osaka, Japan from October 22-26, 2006. Written by authorities in the area, the book provides a thorough overview of progress in the area of magnesium research. The author is one of the world's foremost magnesium researchers and reviewers, and the book provides essential reading for researchers in magnesium.

This is the first book to cover minimal-invasive treatment of osteoporotic, tumorous and traumatic vertebral fractures in the English language. In addition to detailed descriptions of the techniques, including tips and tricks from experts, the book contains a chapter about the medical treatment of osteoporosis, which is indispensable in the interdisciplinary approach to osteoporosis. This acclaimed innovative concept unites several treatment aspects. More conservative treatment methods are also presented in this work.

All chapters reflect new developments and clinical findings in the field of orthopaedics, surgery, traumatology and neurosurgery.

Over the past decade, major advances have taken place in the management of osteoporosis. Newdasses of pharmaceutical agents have been developed, tested, and used to treat millions of patients; education and early detection programs have been instituted around the world; and bone densitometry has received widespread recognition by healthcare agencies as being central to the preven tive health strategy necessary to care for an aging population. With all these advances, scientists continue to explore new methods to understand and treat this disease. The field of orthopaedic surgery has a great opportunity to bring this new information to its dinics and operating rooms. It is critically impor tant that the practicing surgeon be armed with this knowledge. Fractures are dearly the most common orthopaedic problem associated with osteoporosis. The goals of treatment are rapid restoration of mobilityand func tion and return of patients to a level of activity that supports their general health. The ability to control the metabolic condition or to treat the under lying cause of the osteoporosis with pharmacological intervention willimprove surgical results. Moreover, the special techniques required to succeed in the operative treatment of bone, which is already weakened by osteoporosis, must be carefully developed, tested, and understood. This book provides the first attempt to bring this body of information to the orthopaedic surgeon in a dearly organized and comprehensive way. Historically, few orthopaedic surgery or trauma training programs have offered much in the way of education in the science of bone metabolism."

Caring for patients with fibromyalgia requires an understanding of the complex nature of this condition. Fibromyalgia: A Practical Clinical Guide is a state-of-the-art resource designed to clarify the controversy about fibromyalgia and to provide clinicians with the latest information about its pathogenesis and clinical evaluation, as well as evidence-based guidelines for effective treatment. This comprehensive title includes fully referenced, practical information on this fast-emerging field and provides useful clinical suggestions and practical office tools for effectively managing patients. The good news for fibromyalgia patients and their healthcare providers is that a wide range of medication, non-medication, and non-traditional therapies have been proven to effectively reduce some of the most problematic and disabling fibromyalgia symptoms. Brief case vignettes help describe many of the common presentations, concerns, and complexities typically seen in fibromyalgia patients. Invaluable graphic aids -- boxes, tables, and figures - are used widely to provide quick reference for the busy clinician seeking information. In addition, clinic-proven assessment and documentation tools for evaluating and monitoring fibromyalgia symptoms and severity are provided, along with handouts for patients to provide guidance on pain management techniques, including detailed exercise and relaxation technique instructions. A unique addition to the literature, Fibromyalgia: A Practical Clinical Guide is an indispensable reference for all clinicians who care for patients with fibromyalgia.

Originally published in 2007 and now available for the first time in paperback format, Head and Neck Manifestations of Systemic Disease presents critical information on a multitude of maladies that have manifestations in the head and neck. The book relates commonly encountered head and neck symptoms and signs to an array of diseases and disorders that should be considered in the differential diagnosis. Offering a hands-on approach, this volume addresses specific disease classifications and commonly encountered signs and symptoms in the head and neck region. It offers a clinical approach to disease diagnosis by analyzing the possible causes of a patient's symptoms. The contributors present evidence-based therapeutic options for a variety of conditions, from infections and rheumatologic conditions to hematologic and neoplastic disease. Organized by disease type for easy reference, the book offers a variety of lucid color photographs, providing a unique reference for clinicians who manage diseases with symptoms in this region.

T e evaluation of musculoskeletal disorders is of en T is atlas of ers a starting point for orthopedic, ra- problematic because of the variety of diseases and di- ology, and pathology residents. Furthermore, it emp- agnostic complexity. T is is compounded by the in- sizes a team approach and should be attractive to the creasing specialization in this f eld. While a variety of clinician, the rheumatologist, the radiologist, and - recent textbooks give comprehensive coverage of these thologist and of er them the opportunity to familiarize disorders, this color atlas is intended to provide a suc- themselves with and enhance their diagnostic acumen of cinct guide to evaluation and treatment. T e atlas is or- these musculoskeletal conditions. ganized into sections according to diagnosis. T e text T is atlas of clinical orthopedics is a joint ef ort from is brief and gives concise information on the clinical two large institutions, the Orthopedic Department of features, radiographic characteristics and pathologi- Semmelweis University (Hungary) and the musculos- cal features that are important for the diagnosis. T e letal tumor center of Mayo Clinic (USA), both of which reader will appreciate the many illustrations demon- have extensive experience in the dif erent areas of m- strating the characteristic features of musculoskeletal culoskeletal diseases.

This timely volume addresses the areas of pathophysiology and therapy of pulmonary hypertension, which have seen exciting developments over the past decade. The discoveries of endothelin overexpression as well as prostacyclin and nitric oxide deficiency in association with pulmonary hypertension have led to important therapeutic insights. The new therapies have led to significant improvements in patient function, quality of life and survival. In this book, expert authors describe these new therapies. It will be of interest not only to cardiologists, pulmonary specialists and rheumatologists, but also many nurses and pharmacotherapists.