Both scientifically and socially the Vlth International Symposium on Amyloidosis, August 5 - 8, 1990 in Oslo was a great success. There were three and a half intensive days. It started with the Opening Ceremony, particularly highlighted with the Norway-Norway multi media show by David Cochron, and ended with a visit to the Edvard Munch museuro and the Farewell Salmon Dinner on the evening of August 8 (not to forget the "happy birthday" song for Dorothea Zucker-Franklin at the breakfast table the following morning). In between was the intellectual penetration into the science of amyloidosis and amyloid proteins, and a deepening of many friendships among young and old "amyloidologists", together with some of the cultural and historical features of Oslo and Norway. Among the numerous Ietters of thanks and gratitude that we have received, the senior organizer of the previous meeting, Takashi lsobe said it briefly and eloquently: "You have overwhelmed us, you have performed a drama with joy and cheer, you have hosted so nicely with lovely secretariat, you have arranged impressive hospitality in every respect, you certainly did for all of us" Now we are left with the proceedings book for the three coming years until the next symposium in Kingston, Canada, which will be organized by Drs. Robert Kisilevsky and Thomas Muckle from the Department of Pathology at Queens University in 1993. The scientific contributions herein cover all the sessions of the meeting.

Classification of the carpal injuries helps us to understand the relationship between them. The growing interest in this field has been advanced by recent imaging techniques. Therapeutic advice and treatment are still not completely defined, even by the most renowned specialists. There is still room for new concepts.

This edition of the companion volumes Muscle Pain: Understanding the Mech- isms and Muscle Pain: Diagnosis and Treatment is essential reading for those interested in clinical approaches to acute and chronic pain conditions involving muscle tissues and in the mechanisms underlying these conditions. The volumes cover a very important topic in pain medicine, since muscle pain is very common and can often be dif?cult to diagnose and treat effectively. Furthermore, chronic pain involving muscle and other components of the musculoskeletal system increases with age, such that it is a common complaint of those of us who are middle-aged or older. Indeed, as changing population demographics in "west- nized" countries result in higher proportions of the population living longer and being middle-aged and elderly, chronic muscle pain will likely become even more of a health problem. In the case of acute muscle pain, this can often be very intense, and in the short term can limit or modify the use of components of the musculoskeletal system associated with the sensitive muscle. Chronic muscle pain can also be intense, as well as unpleasant and disabling, and it is in many cases the over-riding symptom of most musculoskeletal disorders that are associated with long-term deleterious changes in musculoskeletal function.

This edition of the companion volumes Muscle Pain: Understanding the Mech- isms and Muscle Pain: Diagnosis and Treatment is essential reading for those interested in clinical approaches to acute and chronic pain conditions involving muscle tissues and in the mechanisms underlying these conditions. The volumes cover a very important topic in pain medicine, since muscle pain is very common and can often be dif?cult to diagnose and treat effectively. Furthermore, chronic pain involving muscle and other components of the musculoskeletal system increases with age, such that it is a common complaint of those of us who are middle-aged or older. Indeed, as changing population demographics in "west- nized" countries result in higher proportions of the population living longer and being middle-aged and elderly, chronic muscle pain will likely become even more of a health problem. In the case of acute muscle pain, this can often be very intense, and in the short term can limit or modify the use of components of the musculoskeletal system associated with the sensitive muscle. Chronic muscle pain can also be intense, as well as unpleasant and disabling, and it is in many cases the over-riding symptom of most musculoskeletal disorders that are associated with long-term deleterious changes in musculoskeletal function.

The physiology of man is a complex subject. Unfortunately the regulation of temperature in the human body is not always well explained in textbooks. Many conference proceedings on the subject have been produced that give excellent detail on research topics. However, the subject matter is rarely presented as a composite whole. New technology has broadened the scope of methods available for studying body temperature. Thermography in particular has made it possible to record in real time the temperature distribution of large areas of the body surface. Modem image processing methods permit dynamic studies to be carried out and detailed analyses made retrospectively-a tremendous advance over the complex and slow techniques formerly used by physiologists. Yet although the associa tion between disease and temperature is as old as medicine itself, beyond the implicit faith in the clinical mercury thermometer, other measuring techniques are finding a slow acceptance. This book is designed to put into perspective the critical factors that make up "body temperature. " Body temperature cannot be viewed as a static entity but rather must be seen as a dynamic process. An understanding of this phenomenon is important to all who use thermal imaging and measuring techniques in clinical medi cine. These methods have, in recent years, brought engineers, physi cists, technicians, and clinicians together. Inevitably, however, there v vi Preface are gaps and overlaps in technology and understanding.

Rheumatologic diseases are highly associated with clinical symptoms of the skin, nails, and mucosal membranes. This book provides the practicing rheumatologist with a rapid, easy to consult reference to help interpret the nature of these cutaneous lesions and then quickly decide upon the appropriate follow-up tests. Utilizing an abundance of informative photographs, it contains all of the essential information needed for early diagnosis and treatment. This comprehensive guide properly orients the practitioner within the challenging world of rheumatologic disorders of the skin and gives insight into when consultation with a dermatologist is advisable.

This book presents the essential anatomic and radiological data, discussing new and refined techniques of imaging such that readers may rely on their interpretation. The chapters on pathology are approached in a clinical context, accompanied by numerous diagrams and photographs, while the references, both classical and recent, are profuse. The result is a complete review of the subject, of interest to both the specialist and the non-specialist.

As a phylogenetically old system complement is now regarded as a part of innate immunity. But it is much more than that. It bridges innate and adapted immunity, participates not only in host defense but also in many essential physiological processes, old and new diseases and adverse conditions. Indeed, complement became a term that almost defies categorization. What was for a long time a subject for a limited number of specialists has now moved into the mainstream of experimental and clinical immunology. In 1973 I visited the Basel Institute of Immunology and met its director, the eminent scientist and Nobel laureate Nils Jerne. When I entered his office he greeted me with the following words: "Complement, does that really exist?" I was never certain whether he wanted only to tease me or whether he sincerely believed that the complement system was an unimportant biological curiosity, a misstep of evolution. But, of course, missteps do not survive the evolutionary process. Little did I foresee the dramatic developments of recent years when Hans J. Muller-Eberhard and I started to unravel the specifics of the action of the cobra venom factor on the complement system in 1968 and defined a new pathway to its activation. An elucidation of the role of the system in diseases and its control for therapeutic reasons is now getting closer to actual realization in the clinic although many problems, in particular those of highly specificinhibition free of side effects, have still to be resolved."

In recent years, the techniques of electron microscopy have developed so widely and rapidly that they now cover the fields of research once the unique ll:panage of sister research techniques such as biochemistry, physiology, immunology, X-ray diffraction, etc. It is now possible to reach molecular and submolecular levels, making this technique indispensable in every type of research. Electron microscopy alone often provides enough information to solve given problems. In the field of the connective tissue matrix, knowledge of the molecular structure of collagen, pro teoglycans and elastin and their interaction has been to a large extent elucidated by electron microscopy. The field over which electron microscopy ranges in the investigation of the connective tissue matrix is so wide that the aim of this volume is to collect the main ultrastructural acquisitions disseminated in various journals and monographs in one book. The intent ofthis volume is to: (a) integrate different and new microscopic methods and review the results of such an integrative approach; (b) present a comprehensive ultrastructural account of selected aspects of the field; (c) point out gaps or controversial topics in our knowledge; (d) outline pertinent future research and expansion of the subject.

Despite 50 years of antibiotics, infection remains a major source of both morbidity and mortality. Immunosuppression, either secondary to drugs in transplant recipients or secondary to HIV, has expanded the number of microorganisms that are known to be pathogenic in man. Imaging of infection has a vital role both in the initial diagnosis and in the continuing management of patients with infection or suspected infection. Functional imaging using nuclear medicine techniques has a unique role to play in identifying sites of infection in a wide range of patients with varying clinical conditions. This book, written by a series of experts not just in the fields of nuclear medicine but also infectious disease and radiology, discusses the role of nuclear medicine in three parts: a review of the pathophysiology of infection; a technical description of those nuclear medicine techniques which can be used in imaging infection; an extensive systematic review including thoracic, abdominal and orthopaedic infection as well as a special section on the acutely ill patient, the immunosuppressed patient and the patient with pyrexia of unknown origin. This book will be of interest to all clinicians looking after patients with infection and who need to use imaging techniques. It will also be of use to radiologists and nuclear medicine physicians who will be using these techniques clinically.

Modern society is altering the lifestyle and longevity of its members much more quickly than evolutionary adaptation to these changes can take place. The problem of calcium deficiency in the population is compounded by the growing percentage of aged individuals with relatively fragile, less massive skeletons. Current-day civilizations are much more effective in prolonging human life in a state of relative debility than even a few decades ago. This reality is unlikely to change and mandates that we develop strategies to prevent aging-related diseases like osteoporosis before they become manifest. Osteoporosis: Genetics, Prevention and Treatment places emphasis on the (1) genetic predisposition, (2) early recognition and (3) prevention of osteoporosis. The intent is not to move the practitioner's attention away from intervention therapy of osteoporosis, but rather to expand their view of this disease as one beginning at birth and one in which susceptibility is manifest at the conclusion of adolescence, not at menopause. The book concludes with an informed view of the future in terms of the recognition, prevention and management of osteoporosis.

Leading clinicians and clinical researchers discuss in practical detail the newest treatments used in rheumatic diseases, emphasizing-without neglecting current standard treatments-those experimental therapies now undergoing clinical trials and poised for early introduction into the rheumatology armamentarium. The diseases and therapeutic regimes examined here range from rheumatoid arthritis and its treatment by gene therapy, to osteoarthritis and systemic autoimune diseases. Each chapter is organized so that the busy clinician can quickly obtain all the information needed optimal patient treatment. This includes an analysis of the pathogenic mechanisms that explain the molecular basis of the newer therapeutics, reviews of animal data and the results of clinical trials, and recommendations concerning use, side effects, and precautions.

As it is quick, inexpensive, and non-invasive, ultrasound is the modality of choice for guidance of interventional procedures in the soft tissues. Furthermore, the rising mean age of the general population is being accompanied by increasing demand among patients for minimally invasive procedures to treat painful chronic and degenerative syndromes of the musculoskeletal system. This handbook is a clear, practical guide to ultrasound-guided minimally invasive treatments of musculoskeletal pain in the upper limb. Each chapter is clearly structured, with brief but comprehensive descriptions of the disease to be treated and of the materials and drugs needed. High-quality images and easy-to-follow schemes explain the best approach in each situation, and practical tips and tricks of value in daily clinical routine are provided.

Hughes Syndrome: The Antiphospholipid Syndrome, A Guide for Students provides an in-depth analysis into the main effects of Hughes Syndrome. In 1983, Dr Graham Hughes, and his team in London, described a syndrome and subsequently developed simple blood tests to diagnose the condition. This syndrome is characterised by thrombosis (both in limbs and internal organs), headaches, memory loss, strokes and, in pregnant women, placental clotting and recurrent miscarriage. The syndrome, now known worldwide as Hughes Syndrome, or the Antiphospholipid Syndrome, is common - being responsible for example, for up to 1 in 5 cases of young stroke and more importantly, it is treatable. Hughes Syndrome: The Antiphospholipid Syndrome, A Guide for Students details the effects of Hughes Syndrome on the major organs, making it a valuable reference tool for students in training.

Sparing of the growth plate is an early feature of diaphyseal and meta-diaphyseal osteosarcoma. Capitalising on this characteristic, Jose Canadell has developed an innovative technique to preserve the epiphysis while resecting primary bone malignancies lying adjacent to the growth plate of skeletally immature patients. Using external ? xation devices, controlled distraction of the epiphysis from the growth plate permits iatrogenic separation of the epiphysis from the affected region. Subsequent resection is enhanced by a safe distal margin and Canadell's local control rates attest to the success of the procedure as an oncologically sound technique. The Canadell technique has been developed through rigorous examination of the behaviour of osteosarcoma, as well as an interrogation of the best modalities for assessing tumour invasion of the growth plate. Combining an innovative treatment philosophy with a sound knowledge of the behaviour of osteosarcoma and basic bone and growth plate biology, as well as an extensive experience with ancillary investigations and adjuvant therapies, Canadell has developed a robust surgical technique for the management of a challenging tumour in selected patients. This book is the culmination of Canadell's endeavours over the last two decades. It traces the steps that he has taken to validate the safety and ef? cacy of the Canadell technique as we know it today.

Ankylosing Spondylitis in Clinical Practice is a concise, practical guide on the diagnosis and management of this debilitating condition. This book is aimed at clinicians who treat Ankylosing Spondylitis. It provides an authoritative, accessible guide to the diagnosis, management and treatment of ankylosing spondylitis.

This timely volume addresses the areas of pathophysiology and therapy of pulmonary hypertension, which have seen exciting developments over the past decade. The discoveries of endothelin overexpression as well as prostacyclin and nitric oxide deficiency in association with pulmonary hypertension have led to important therapeutic insights. The new therapies have led to significant improvements in patient function, quality of life and survival. In this book, expert authors describe these new therapies. It will be of interest not only to cardiologists, pulmonary specialists and rheumatologists, but also many nurses and pharmacotherapists.

Lupus is an extremely common, potentially treatable, disease of the immune system. It affects approximately 1 in 1000 women and is more common than diseases such as multiple sclerosis and leukaemia. Despite this, there is little information concerning the disease in contrast to other illnesses of similar prevalence.

Many people are unaware of the symptoms, treatment, and prevention of lupus. It is important that these topics are highlighted for many reasons. For example, a greater understanding of the symptoms of lupus will enable patients to recognise the symptoms earlier, and get treatment faster; before any serious damage is done. Similarly, awareness of preventative measures may reduce the number of cases of lupus that occur.

From a different perspective, it would be of great use to have an easily accessible source of information available to lupus patients that would highlight issues such as treatment options and sources of support.

In summary, although knowledge of lupus is growing, greater awareness of the disease amongst both patients and the general public is an issue that needs to be addressed.

The assessment and management of rheumatic diseases is challenging and many doctors are not confident of their abilities in this area. Those who want to rapidly learn the essentials of modern clinical rheumatology will find all the practical advice and information they need in this text. Written for senior house officers and residents in general (internal) medicine, health professionals in rheumatology, primary care doctors and medical students will also find it useful: Up-to-date information about new therapies Essentials of common and uncommon rheumatic diseases listed Practical advice on selecting appropriate tests, drug prescribing and patient information Patient-centred approach to management Useful rheumatology websites listed All you need in one handy pocket-sized resource

This book is written primarily for occupational therapists and occupational therapy students but will be of relevance to anyone working with clients with rheumatoid disease. It is hoped that the text will communicate the challenge faced by therapists to establish management programmes appropriate to the identified needs and priorities of the individuals with whom they work, the potential to utilize a wide range of skills and the opportunity to contribute to the understanding of the many unanswered questions which remain in relation to rheumatic diseases. The aim of this book is to present an holistic approach to the management of rheumatoid disease, considering first, the ways in which rheumatoid disease can affect a person's life and then looking at the approaches and techniques used by therapists to minimize these effects. This approach has been chosen as it is fundamental to both the philosophical basis of occupational therapy and the manage ment of a chronic progressive disease. An holistic approach considers the physical, psychological, social and spiritual aspects of a person and the ways in which these have been effected by an underlying disease process. Each of the components are interrelated, illustrating the complexity of establishing appropriate management programmes and evaluating their effectiveness. The first two chapters consider the effects of rheumatoid disease on clients and their families. An holistic approach identifies the need for a diversity of skills to be available to both the therapist and client.

Compiled by Cochrane collaborators and members of OMERACT (Outcome Measures in Rheumatology), "Evidence-based Rheumatology" is an essential resource for evidence-based medicine as applied to the musculoskeletal disorders.

The introductory section covers the principles of evidence-based medicine in rheumatology, followed by clinical chapters covering all the major disorders. Each chapter includes non-drug therapy, drug therapy, and consumer evidence-based summaries.

Evidence-Based Series: "Evidence-based Rheumatology," part of the acclaimed series BMJ Evidence-based medicine textbooks that have revolutionised clinical medicine literature, comes with a fully searchable CD-ROM of the whole text. The text is kept up to date online at www.evidbasedrheum.com

Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file.

Gone are the days when the physician could act as God, the orthopaedic surgeon as the Lord God and the nurses as minister ing angels. The concept of a team approach with each discipline supplying special yet overlapping skills is accepted in principle, although not always in practice. Physiotherapists and occupational therapists resist integration of their training among the hierarchy; however, on the ground, these remedial therapists often do each other's jobs with remarkable amity. Elsewhere I have discussed whether we need multipurpose professionals or multiprofessional persons (Wright 1982). At Leeds the close collaboration that exists between rheumatol ogists and non-medically qualified professionals has resulted in a productive Bioengineering Group for the Study of Human Joints, a Clinical Pharmacology Unit of international renown and a Rehabilitation Unit that consistently produces bricks without straw. One aspect of this combined approach to patient care has been the development of the discipline of clinical nurse metrology (Bird et al. 1980). Skilled nursing sisters have worked in this capacity for a decade in Leeds. Their contribution has not only enhanced the reliability of the results of clinical trials in which they have been engaged, but it has been highly s;ost effective and greatly appreciated by patients. It has also measurably improved our patient education programme. Moreover, the posts have provided considerable job satisfaction. This book arises from the expertise gained during these pioneer years."

The highest-yield musculoskeletal radiology exam prep and learning tool available today! Top 3 Differentials in Musculoskeletal Imaging: A Case Review by Jasjeet Bindra, Robert D. Boutin, and expert contributors is one in a series of radiology case books mirroring the format of the highly acclaimed O'Brien classic, Top 3 Differentials in Radiology: A Case Review. The book is organized in 10 parts: trauma, bone tumors, upper extremity, lower extremity, arthropathies, infection, soft tissue tumors, metabolic musculoskeletal conditions, spine, and pediatric/developmental musculoskeletal conditions. Each case is formatted as a two-page unit. The left page features clinical images, succinctly captioned findings, and pertinent clinical history. The right page includes the key imaging gamut, differential diagnoses, additional diagnostic considerations, the diagnosis, clinical pearls, and suggested readings. Key Features A total of 146 cases, each focused on a specific imaging finding, including aggressive periosteal reaction, focal cortical thickening, diffusely increased bone density, focal periphyseal edema, acro-osteolysis, and more A wealth of meticulously selected, high-quality radiographs, CTs, and MRIs enhance diagnostic skills A list of differential diagnoses provides an ideal curriculum guide for trainees and educators alike Radiology residents, fellows, and staff radiologists preparing for certification will greatly benefit from reading this text to prep for the radiology core and certifying exams. This is also an outstanding, day-to-day practice resource for practicing radiologists, clinicians, and orthopaedic surgeons involved in reviewing and interpreting musculoskeletal radiology studies. This book includes complimentary access to a digital copy on https://medone.thieme.com.

More than 140 years ago, lupus erythematosus (LE) was recognized as a disease entity by clinicians working in the field of dermatology, which had only recently become an independent medical discipline. Soon after cutaneous lupus was first reported, it was realized that, apart from the skin, the disease could involve other organs and thus be systemic in nature. The latter observations were first made by MORITZ KApOSI [1], whose work has attracted renewed attention re cently and who succeeded FERDINAND VON HEBRA to the chair of dermatology at the Medical Faculty in Vienna. The early description of lupus erythematosus in both its cutaneous and systemic manifes tations was thus intimately associated with Vienna and its Medical School. The next phase in the study of lupus was characterized by an in crease in knowledge of the type and extent of organ involvement. The work by OSLER [2], LIBMANN and SACKS [3], and KLEMPERER [4] best represents these advances. The increase in clinical knowledge of LE finally led to DUBOIS' famous monograph [5], which was pub lished at a time of renewed interest in SLE, elicited by the descrip tion by HARGRAVES et al. [6] of the LE-cell phenomenon. A more detailed analysis of this finding revealed that the disease was charac terized by an abnormal immune response, although its pathogenetic implications were still unclear.