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Books > Medicine > Clinical & internal medicine > Rheumatology

Challenging Cases in Rheumatology and Diseases of the Immune System (Hardcover, 2013 ed.): Massoud Mahmoudi Challenging Cases in Rheumatology and Diseases of the Immune System (Hardcover, 2013 ed.)
Massoud Mahmoudi
R5,626 Discovery Miles 56 260 Ships in 10 - 15 working days

Rheumatology is a branch of medicine studying abnormalities and diseases of the musculoskeletal system: Joints, muscles, and connective tissues. Immunology is a branch of medicine studying abnormalities and diseases of our immune system. Immune diseases are either due to deficiency of the immune system leading to "immunodeficiency" or due to failure of recognizing the "self" from "non-se'f" and attacking the own system, leading to "autoimmune disease," or due to hypersensitivity diseases such as allergic rhinitis. Rheumatic and Immunologic diseases are closely related because the underlying etiology of certain rheumatic diseases is abnormality of the immune system. Understanding the immune system is the key factor in recognizing the abnormalities in rheumatic diseases. Therefore, clinical immunologists and rheumatologist may occasionally see and treat similar conditions. In fact some specialists are dually trained in Allergy/Immunology and Rheumatology. What makes these two branches of medicine different is their uniqueness. Rheumatologists for example evaluate and treat arthritis (diseases of the joints) such as rheumatoid arthritis, osteoarthritis, and fibromyalgia, to name a few. Allergists and clinical Immunologists treat hypersensitivities such as allergic rhinitis, bee sting allergy, and allergic asthma, and immunological diseases such as immunodeficiencies among others. Both specialists, however deal with autoimmune diseases. Why a Book in Immunology and Rheumatology? Our musculoskeletal structure holds and protects our internal organs. Any insult to such structure, excluding acute bone fractures, results in various conditions known as rheumatic diseases. Whether the involved area is a joint, a cartilage, or a muscle, the understanding of the immune system helps to elucidate the mechanisms of such diseases. As the population ages in the 21st century, the role of rheumatology and Immunology becomes more apparent and appreciated. Approaching a patient with multiple rheumatic diseases is not an easy task. In fact our immense system is perhaps the most complicated system of the human body; this is due to presence and interactions of myriad of cells and chemical mediators that participate in complex pathways such as the inflammatory response and others to defend the body and respond to pathogens. In addition, our immune system protects us against further exposure to harmful substances. Although there are several books on the subjects of immunology and rheumatology, this case-based study of these two subjects is a unique way of reviewing and discussing such complicated areas of medicine. The Book Format: This book will be divided into 6 parts and 16 chapters. The Estimated length: 300-350 manuscript pages. As with the previous titles I have edited (and which have received very favorable reviews), each chapter will consist of 2 or more cases with discussion, and 5 multiple choice questions per case. This title will be similar to Challenging Cases in Pulmonology (Springer 2011), and Challenging Cases in Allergic and Immunologic Diseases of the Skin (Springer, 2010), Challenging Cases in Allergy and Immunology (Humana Press, 2009).

Review of Rheumatology (Hardcover, 2012): Nona T Colburn Review of Rheumatology (Hardcover, 2012)
Nona T Colburn
R3,189 Discovery Miles 31 890 Ships in 10 - 15 working days

Review of Rheumatology is a synopsis of key areas of interest, making for an indispensable quick reference work. The material included reviews basic musculoskeletal anatomy, immunology, genetics, major rheumatic diseases and their pathophysiology, and major rheumatic therapeutics, as well as a unique chapter on the emerging autoinflammatory diseases.

Review of Rheumatology is a clear and concise review book written in an outline format. This book is a quick and easily accessible reference not only for those preparing for the rheumatology board exams, but it also serves as a succinct reference for all health care workers interested in the field of rheumatology.

Understanding Evidence-Based Rheumatology - A Guide to Interpreting Criteria, Drugs, Trials, Registries, and Ethics (Hardcover,... Understanding Evidence-Based Rheumatology - A Guide to Interpreting Criteria, Drugs, Trials, Registries, and Ethics (Hardcover, 2014 ed.)
Hasan Yazici, Yusuf Yazici, Emmanuel Lesaffre
R4,294 R3,712 Discovery Miles 37 120 Save R582 (14%) Ships in 12 - 17 working days

It is imperative that health professionals caring for patients with rheumatic diseases understand how to correctly interpret evidence in their field, taking into account the merits and shortcomings of available data. "Understanding Evidence-Based Rheumatology"offers a practical assessment of criteria, drugs, trials, and registries and provides useful tools for successfully interpreting this data. The book introduces readers to basic analysis of trial design, statistics and application of data through no-nonsense, easy-to-follow insights. Using numerous examples, chapters outline the difficulties physicians encounter when measuring disease activity in rheumatology and offer strategies for systematically approaching these situations. Ethical issues in study design and reporting are examined and the book closes with a summary of future directions for scientific and clinical studies in rheumatology.

"Understanding Evidence-Based Rheumatology"is an invaluable resource for trainees, clinicians and scientists, preparing them with the necessary tools to correctly gather evidence and shed light on the difficult practice of rheumatology."

Glucocorticoids (Hardcover): Nicolas J. Goulding, R.J. Flower Glucocorticoids (Hardcover)
Nicolas J. Goulding, R.J. Flower
R2,651 Discovery Miles 26 510 Ships in 12 - 17 working days

Following 50 years of glucocorticoid use in a clinical setting, an international body of expert scientists and physicians presents the most expansive survey of glucocorticoid pharmacology to date. This work traces the history of glucocorticoid biology from the seminal description of glucocorticoid insufficiency by Thomas Addison in the mid-19th century, up to current advances in elucidating the molecular basis of glucocorticoid action. Important discoveries are presented, as well as milestones in drug development, a survey of current clinical practice, and prospects for novel glucocorticoid-based therapeutics. Scientists and clinicians will appreciate the scope of this work, which is of special interest to workers in the fields of endocrinology, inflammation and autoimmune disease.

Oxford Desk Reference: Rheumatology (Hardcover): Richard Watts, Gavin Clunie, Frances Hall, Tarnya Marshall Oxford Desk Reference: Rheumatology (Hardcover)
Richard Watts, Gavin Clunie, Frances Hall, Tarnya Marshall
R5,207 Discovery Miles 52 070 Ships in 12 - 17 working days

Rheumatology is an ever-changing specialty in which the amount of available information is growing daily and spread across a myriad of books, journals, and websites. The Oxford Desk Reference: Rheumatology brings this information together in an easy-to-use format. This essential resource combines up-to-date, relevant, evidence-based information with the latest guidelines and the experience of senior consultants.
The book is designed such that each subject forms a self-contained topic in its own right, laid out across two or four pages to faciliate the key aim of rapid and easy access to information. This makes the information included simple to find, read and absorb, so that the book can be consulted in the clinic or ward setting for information on the optimum management of a particular condition.
Written by internationally renowned rheumatology consultants, with expert contributors for each section, this book is a must-have resource for all rheumatologists and an excellent reference for all doctors.

Contraception and Pregnancy in Patients with Rheumatic Disease (Hardcover, 2014): Lisa R. Sammaritano, Bonnie L. Bermas Contraception and Pregnancy in Patients with Rheumatic Disease (Hardcover, 2014)
Lisa R. Sammaritano, Bonnie L. Bermas
R5,170 Discovery Miles 51 700 Ships in 12 - 17 working days

Rheumatic (or systemic autoimmune) diseases disproportionately affect young women: the female-to-male ratio for patients with systemic lupus erythematosus during the reproductive years is approximately 9:1. In the mid- to late-twentieth century, women with rheumatic disease diagnoses were often advised to avoid pregnancy due to fear of disease exacerbation and adverse outcome. In more recent years, many women with rheumatic disease have deferred childbearing until a later age due to active disease or unsafe therapies. However, with advances in rheumatology therapies, obstetric monitoring, and reproductive medicine technologies, increasing numbers of women with rheumatic diseases are pursuing pregnancy. As a result, obstetricians and rheumatologists need to be aware of the current state of knowledge and the recommendations for management of pregnancy in these patients. Contraception and Pregnancy in Patients with Rheumatic Disease explains the basics of contraception, fertility treatment, and pregnancy in rheumatic disease patients and serves as a guide and reference tool for both rheumatologists and OB/GYNs. Most general rheumatologists and OB/GYNs have limited experience in caring for rheumatic disease patients during pregnancy, and many do not have ready access to expert colleagues in this area. This book summarizes the current state of knowledge and presents a general approach for assessment of the rheumatic disease patient considering pregnancy, hormonal contraception or infertility treatment.

Hypermobility of Joints (Hardcover, 4th ed. 2012): Peter H Beighton, Rodney Grahame, Howard Bird Hypermobility of Joints (Hardcover, 4th ed. 2012)
Peter H Beighton, Rodney Grahame, Howard Bird
R3,030 Discovery Miles 30 300 Ships in 10 - 15 working days

Hypermobility of Joints 4th Edition follows the same format as its successful predecessors. The aim of which was to provide an overview of hyperlaxity of joints and this edition follows that aim by describing the most recent research and new developments in biochemistry, as well as providing practical advice on clinical features and management.

Hypermobility of Joints 4th Edition provides illustrative case histories, a review of hypermobility in the performing arts and sports and an outline of heritable hypermobility syndromes. This book is a valuable reference tool for a wide number of specialties, although it will particularly be of interest to rheumatologists, orthopedic surgeons and medical geneticists.

All About Fibromyalgia - A Guide for Patients and their Families (Hardcover, 2): Daniel J. Wallace, Janice Brock Wallace All About Fibromyalgia - A Guide for Patients and their Families (Hardcover, 2)
Daniel J. Wallace, Janice Brock Wallace
R1,519 Discovery Miles 15 190 Ships in 12 - 17 working days

In All About Fibromyalgia, the authors provide a thoroughly revised and updated version of the highly successful Making Sense of Fibromyalgia, which was endorsed by the Arthritis Foundation, Southern California Chapter. This new volume continues to provide a comprehensive guide - for both patients and professionals - to this little known and poorly understood syndrome. It has now also been completely updated with the current understanding of the disease, and includes information on the latest drug treatments.

Systemic Corticosteroids for Inflammatory Disorders in Pediatrics (Hardcover, 2015 ed.): Rolando Cimaz Systemic Corticosteroids for Inflammatory Disorders in Pediatrics (Hardcover, 2015 ed.)
Rolando Cimaz
R4,141 R3,558 Discovery Miles 35 580 Save R583 (14%) Ships in 12 - 17 working days

This comprehensive volume provides current state of the art of the use of corticosteroids in the pediatric patient. It consists of 14 chapters written by leading authors from different countries. The first chapters cover historical notes, general concepts on treatment with corticosteroids with regard to indications and side effects, and basic pharmacologic properties of these compounds. The rest of the book is devoted to the specific use of steroids in the different pediatric subspecialties. Despite advances with newer effective immunosuppressive and anti-inflammatory drugs, corticosteroids still remain the mainstay of therapy for many disorders. Leading authors in their field have summarized these concepts to provide an authoritative, comprehensive guide to help clinicians safely and effectively use corticosteroids in their pediatric patients.

Studies on Arthritis and Joint Disorders (Hardcover, 2013 ed.): Maria Jose Alcaraz, Oreste Gualillo, Olga Sanchez-Pernaute Studies on Arthritis and Joint Disorders (Hardcover, 2013 ed.)
Maria Jose Alcaraz, Oreste Gualillo, Olga Sanchez-Pernaute
R6,984 Discovery Miles 69 840 Ships in 12 - 17 working days

This next volume in our established series proposes to systematically review the basic science and clinical knowledge of the role of free radicals and antioxidants, collectively known as "oxidative stress", in the pathology of arthritis and other joint diseases. It will describe the most current diagnostic tools , laboratory methods and technology, to suggest ways of prevention and treatment and to emphasize the concept of the bench-to-bedside approach. The book will also provide specific coverage on emerging technology and medical applications including discussions of biomarkers and antioxidants as therapeutic agents and several more relevant aspects. In addition, the book will promote the concept of using biomarkers representative of oxidative stress reactions and free radical damage , as well as describe the effect of antioxidants in treating disease in clinical trials. The content will be valuable to researchers studying the development of arthritis/joint disease, and clinicians treating patients with these diagnoses.

Prognosis in the Rheumatic Diseases (Hardcover, New): N. Bellamy Prognosis in the Rheumatic Diseases (Hardcover, New)
N. Bellamy
R2,678 Discovery Miles 26 780 Ships in 12 - 17 working days

1 Introduction.- 2 Osteoarthritis.- 3 Rheumatoid arthritis.- 4 Juvenile arthritis.- 5 Crystal-associated arthropathies.- 6 Ankylosing spondylitis.- 7 Psoriatic arthritis.- 8 Reiter's syndrome.- 9 Systemic lupus erythematosus.- 10 Systemic sclerosis (scleroderma).- 11 Polymyositis-dermatomyositis.- 12 Vasculitis.- 13 Polymyalgia rheumatica and giant cell arteritis.- 14 Arthritis in pregnancy.- 15 Fibromyalgia.- 16 Low back pain.- 17 Prediction of the clinical efficacy of and intolerance to antirheumatic drug therapy.- 18 Prediction of organ system toxicity with anti-rheumatic drug therapy.- 19 New concepts in prognosis of rheumatic diseases for the 1990s.

The Nature and Functions of Dreaming (Hardcover, New): Ernest Hartmann The Nature and Functions of Dreaming (Hardcover, New)
Ernest Hartmann
R1,807 Discovery Miles 18 070 Ships in 12 - 17 working days

The Nature and Function of Dreaming presents a comprehensive theory of dreaming based on many years of psychological and biological research by Ernest Hartmann and others. Critical to this theory is the concept of a Central Image; in this volume, Hartmann describes his repeated finding that dreams of being swept away by a tidal wave are common among people who have recently experienced a trauma of some kind - a fire, an attack, or a rape. Dreams with these Central Images are not dreams of the traumatic experience itself, but rather the Central Image reveals the emotional response to the experience. Dreams with a potent Central Image, like the tidal wave, vary in intensity along with the severity of the trauma; this pattern was shown quite powerfully in a systematic study of dreams occuring before and after the September 11 attacks in New York.
Hartmann's theory comprises three fundamental elements: dreaming is simply one form of mental functioning, occurring along a continuum from focused waking thought to reverie, daydreaming, and fantasy. Second, dreaming is hyperconnective, linking material more fluidly and making connections that aren't made as readily in waking thought. Finally, the connections that are made are not random, but rather are guided by the dreamer's emotions or emotional concerns - and the more powerful the emotion, the more intense the Central Image.

IgG4-Related Disease (Hardcover, 1st ed. 2017): Kazuichi Okazaki IgG4-Related Disease (Hardcover, 1st ed. 2017)
Kazuichi Okazaki
R4,130 Discovery Miles 41 300 Ships in 10 - 15 working days

This volume focuses on IgG4-related disease (IgG4-RD), a novel clinical entity involving multiple organs and of unknown origin, associated with the abundant infiltration of IgG4-positive cells. It consists of nine chapters written by prominent experts in the field and discusses the disease concept, diagnosis and treatment, as well as recent findings on its pathogenesis and pathophysiology. As such, it offers an invaluable source of information for researchers and clinicians alike.

Muscle Pain: Diagnosis and Treatment (Hardcover, 2010 ed.): Siegfried Mense, Robert D. Gerwin Muscle Pain: Diagnosis and Treatment (Hardcover, 2010 ed.)
Siegfried Mense, Robert D. Gerwin
R9,944 Discovery Miles 99 440 Ships in 12 - 17 working days

This edition of the companion volumes Muscle Pain: Understanding the Mech- isms and Muscle Pain: Diagnosis and Treatment is essential reading for those interested in clinical approaches to acute and chronic pain conditions involving muscle tissues and in the mechanisms underlying these conditions. The volumes cover a very important topic in pain medicine, since muscle pain is very common and can often be dif?cult to diagnose and treat effectively. Furthermore, chronic pain involving muscle and other components of the musculoskeletal system increases with age, such that it is a common complaint of those of us who are middle-aged or older. Indeed, as changing population demographics in "west- nized" countries result in higher proportions of the population living longer and being middle-aged and elderly, chronic muscle pain will likely become even more of a health problem. In the case of acute muscle pain, this can often be very intense, and in the short term can limit or modify the use of components of the musculoskeletal system associated with the sensitive muscle. Chronic muscle pain can also be intense, as well as unpleasant and disabling, and it is in many cases the over-riding symptom of most musculoskeletal disorders that are associated with long-term deleterious changes in musculoskeletal function.

RheumaDerm - Current Issues in Rheumatology and Dermatology (Hardcover): Carmel Mallia, Jouni Uitto RheumaDerm - Current Issues in Rheumatology and Dermatology (Hardcover)
Carmel Mallia, Jouni Uitto
R2,705 Discovery Miles 27 050 Ships in 12 - 17 working days

This text represents the proceedings of a conference, Rheumaderm, that was held in December 1997. The meeting was a dialogue between the specialties of Rheumatology and Dermatology, exploring and discussing areas of common interest. The aim was to present problems common to both specialties, thereby emphasizing the team approach to such problems and helping to combine various skills.

Antiphospholipid Antibody Syndrome - From Bench to Bedside (Hardcover, 2015 ed.): Pier-Luigi Meroni Antiphospholipid Antibody Syndrome - From Bench to Bedside (Hardcover, 2015 ed.)
Pier-Luigi Meroni
R3,051 Discovery Miles 30 510 Ships in 10 - 15 working days

This book, part of the series Rare Diseases of the Immune System, offers comprehensive, up-to-date coverage of the pathophysiology and management of the antiphospholipid syndrome (APS). Immunologic and genetic aspects are discussed and the pathogenic mechanisms responsible for such phenomena as APS-mediated thrombosis and pregnancy loss/complications are explained. The main clinical manifestations, classification criteria and diagnostic tools are identified, and close attention is paid to the nature of the involvement of various organs or organ systems in APS. Specific chapters describe the treatment of the different symptoms, therapies of value in avoiding recurrences, and innovative treatment approaches. The authors are senior experts in the field who are aided by younger fellows, ensuring that the book is also educationally oriented. This handy volume will be a valuable tool for postgraduates in training and professionals wishing to extend their knowledge of this specific syndrome.

New Concepts in Pathology and Treatment of Autoimmune Disorders (Hardcover, 2001 ed.): C. Pozzilli, P. Pozzilli, J.-F. Kapp New Concepts in Pathology and Treatment of Autoimmune Disorders (Hardcover, 2001 ed.)
C. Pozzilli, P. Pozzilli, J.-F. Kapp
R3,020 Discovery Miles 30 200 Ships in 10 - 15 working days

Autoimmunity, characterized by autoreactive lymphocytes and autoantibodies, is the consequence of a failure to discriminate between self and non-self, and autoimmune diseases are an increasing threat to people living in the industrialized countries. Autoimmune disorders are treatable, but not curable, and patients can face disability at later stages of the disease. Thus, there is a medical and economic need for new concepts and treatments in autoimmune disorders. New concepts and treatments can only be achieved by an interdisciplinary approach bringing together expertise, technologies, and clinical experience. The workshop focused on multiple sclerosis, rheumatoid arthritis and type I diabetes, and discussed conventional drug therapies, gene therapy, cell and tissue transplantation therapies, and first treatments using blood stem cells for reprogramming the patients' immune system.

Manual of Biological Markers of Disease, Section B - Autoantigens (Hardcover, illustrated edition): W.J.Van Venrooij, Ravinder... Manual of Biological Markers of Disease, Section B - Autoantigens (Hardcover, illustrated edition)
W.J.Van Venrooij, Ravinder Maini
R2,681 Discovery Miles 26 810 Ships in 12 - 17 working days

The first section of this volume provides well structured protocols for autoantibody detection. Step-by-step procedures are accompanied by explanatory notes and comments, clear diagrams, line illustrations and excellent photo illustrations. Extensive literature references lead the way to further background information. The methods presented were validated by more than 40 leading laboratories active in sera analysis, which indicates that these methods have been found to be practically useful and lead to consistent inter-laboratory results: consensus in autoantibody detection. The second section contains the a compilation of full, detailed information on autoantigens related to important autoimmune diseases. The chapters are all structured according to an easy-reference fixed template structure: specific detection methods, cellular localization, biochemical characteristics, function, cDNA and derived amino acid sequence, gene structure, B- and T-cell epitopes and lists of published monoclonal antibodies. The text is enhanced by many schematic figures and photo illustrations. As in Section A, extensive literature references are provided. The information for this section was brought together by leading experts in their fields. This Manual is intended as a reference book for bench scientists working in the field of autoimmunity, but also for rheumatologists, general (internal medicine) physicians or clinical immunologists caring for patients with autoimmune disorders.

Skeletal Muscle Mechanics - From Mechanisms to Function (Hardcover): W. Herzog Skeletal Muscle Mechanics - From Mechanisms to Function (Hardcover)
W. Herzog
R9,800 Discovery Miles 98 000 Ships in 12 - 17 working days

Skeletal Muscle Mechanics: From Mechanisms to Function summarises the variety of approaches used by today’s scientist to understand muscle function and the mechanisms of contraction. This book contains research by leading scientists from numerous fields using many different scientific techniques. Topics covered include:

  • Cellular and molecular mechanisms of skeletal muscle contraction
  • Historical perspective of muscle research
  • The newest developments in techniques for the determination of the mechanical properties of single cross-bridges
  • Theoretical modelling of muscle contraction and force production
  • Multifaceted approaches to determine the in vivo function of skeletal muscle
This state-of-the-art account is written by internationally recognised authors and will be a valuable resource to researchers of biomechanics in sports science and exercise physiology.

"I expect this book to be excellent and timely." Professor R. McNeill Alexander FRS, School of Biology, University of Leeds, UK

Recent Progress in Rheumatology (Hardcover): Mary Kellar Recent Progress in Rheumatology (Hardcover)
Mary Kellar
R3,035 Discovery Miles 30 350 Ships in 12 - 17 working days
Bone-Metabolic Functions and Modulators (Hardcover, 2012): Felix Bronner, Mary C. Farach-Carson, Helmtrud I. Roach Bone-Metabolic Functions and Modulators (Hardcover, 2012)
Felix Bronner, Mary C. Farach-Carson, Helmtrud I. Roach
R4,649 Discovery Miles 46 490 Ships in 10 - 15 working days

Recent research, which Bone- Metabolic Function and Modulators expands on, has added new support to the idea that bone not only serves as a support system, but also functions as an integrating organ, with a significant regulatory role for lipid and energy metabolism. Links between physical activity and the skeleton are also becoming increasingly clear. This fully illustrated volume contains up-to-date information on the metabolic role of the skeleton and what this can mean for the treatment of metabolic as well as skeletal and auditory diseases. Bone- Metabolic Function and Modulators is of particular interest to clinician scientists, clinical and basic bone researchers, orthopedists, endocrinologists, internists, dentists, nurse practitioners, medical and dental residents and physiotherapists as well as students of the musculoskeletal system. Bone- Metabolic Function and Modulators is the seventh volume in the series Topics in Bone Biology, edited by Felix Bronner and Mary C. Farach-Carson. Other titles in this series:- Bone Formation Bone Resorption Engineering of Functional Skeletal Tissues Bone and Osteoarthritis Bone and Cancer Bone and Development Bone- Metabolic Function and Modulators is of particular interest to clinician scientists, clinical and basic bone researchers, orthopedists, endocrinologists, internists, dentists, nurse practitioners, medical and dental residents and physiotherapists as well as students of the musculoskeletal system. Bone- Metabolic Function and Modulators is the seventh volume in the series Topics in Bone Biology, edited by Felix Bronner and Mary C. Farach-Carson. Other titles in this series:- Bone Formation Bone Resorption Engineering of Functional Skeletal Tissues Bone and Osteoarthritis Bone and Cancer Bone and Development Bone- Metabolic Function and Modulators is of particular interest to clinician scientists, clinical and basic bone researchers, orthopedists, endocrinologists, internists, dentists, nurse practitioners, medical and dental residents and physiotherapists as well as students of the musculoskeletal system. Bone- Metabolic Function and Modulators is the seventh volume in the series Topics in Bone Biology, edited by Felix Bronner and Mary C. Farach-Carson. Other titles in this series:- Bone Formation Bone Resorption Engineering of Functional Skeletal Tissues Bone and Osteoarthritis Bone and Cancer Bone and Development

Principles of Molecular Rheumatology (Hardcover, 2000 ed.): George C. Tsokos Principles of Molecular Rheumatology (Hardcover, 2000 ed.)
George C. Tsokos
R6,029 Discovery Miles 60 290 Ships in 10 - 15 working days

George Tsokos and a panel of authoritative clinicians and researchers synthesize the latest findings from across cell and molecular biology with the basic principles of rheumatology to create the first textbook of molecular rheumatology. These established experts describe the biochemical mechanisms by which apoptosis, cell signaling, complement, lipids, and viruses contribute to disease expression, and detail both immune and nonimmune cell function in rheumatic diseases. Their review of the major rheumatic diseases integrates the cellular, biochemical, and molecular biological mechanisms that are important in rheumatic disease pathogenesis. Path-breaking and illuminating, Principles of Molecular Rheumatology expands the envelope of clinical understanding to reveal the biological roots underlying rheumatologic disease, as well as the nature and roles of the powerful new therapeutics now emerging for its optimal treatment.

IgM and Its Receptors and Binding Proteins (Hardcover, 1st ed. 2017): Hiromi Kubagawa, Peter D. Burrows IgM and Its Receptors and Binding Proteins (Hardcover, 1st ed. 2017)
Hiromi Kubagawa, Peter D. Burrows
R3,966 Discovery Miles 39 660 Ships in 12 - 17 working days

This volume reviews the current state of research on the IgM antibody and its multiple receptors and binding proteins. Interactions of the IgM ligands with these molecules are important for protection against infections as a first line of defense, as well as for regulation of immune responses to pathogens and self-antigens. The book includes up-to-date information on: (i) the phylogeny of three IgM-binding receptors [polymeric Ig receptor (pIgR), Fc receptor for both IgA and IgM (Fc /R), and Fc receptor for IgM only (FcR)]; (ii) the lymphocyte-restricted distribution and unique ligand-binding activity of FcR; (iii) the definition and potential function of Fc receptor-like molecule A (FCRLA) as a resident endoplasmic reticulum protein that binds IgM, but also IgG and IgA; (iv) IgM antibody-mediated enhancement of humoral immune responses, highlighting the importance of complement and its receptors, (v) the numerous important roles of IgM natural antibodies in regulation of inflammation. It is an invaluable resource for researchers and clinicians alike.

Adamantiades-Behcet's Disease (Hardcover, 2003 ed.): Christos Zouboulis Adamantiades-Behcet's Disease (Hardcover, 2003 ed.)
Christos Zouboulis
R6,468 Discovery Miles 64 680 Ships in 10 - 15 working days

It is with great pleasure that I write this Foreword to the Proceedings of the International Conference on Behcet's Disease which was held in Berlin in June 2002. This was the first International Conference held under the auspices of the International Society for Behcet's Disease which was founded in 2000 in Seoul. First, I congratulate our colleagues in Berlin, led by Professor Christos Zouboulis of the Department of Dermatology at the Free University of Berlin, for having organised a most successful conference and for having compiled these proceedings so rapidly. It will be realised immediately on scanning the contents of this book that the conference was truly international with 210 participants from 26 countries, as Professor Zouboulis has noted in his preface. These included basic scientists, epidemiologists, pathologists, clinicians and, importantly, representatives from patient organisations. The latter held their own conference alongside the scientific-medical conference to mutual benefit. The combined session of patients and doctors (abstracts on pp 601 - 626) gave the opportunity for an exchange of information and fruitful discussion. The wide ranging scope of the communications is evident from the index and it was most encouraging to see their origin - from all parts of the world, from senior and junior colleagues and, from many different disciplines. Many communications may be regarded as preliminary reports of research in progress and we look forward to seeing the definitive publications in appropriate journals in due course."

Behcet's Syndrome (Hardcover, 2010 Ed.): Yusuf Yazici, Hasan Yazici Behcet's Syndrome (Hardcover, 2010 Ed.)
Yusuf Yazici, Hasan Yazici
R5,934 Discovery Miles 59 340 Ships in 10 - 15 working days

Behcet s Syndrome has seen great strides over the last two decades in the availability of new treatments and the understanding of underlying pathogenesis. Only 30 years ago the majority of particularly young men with Behcet s lost total eye sight, now only a minority do. This book covers the most recent developments in the basic and clinical aspects of Behcet s Syndrome. International authorities have collaborated to offer their diverse expert knowledge on the multiple affected organs and systems, including the skin, the eye, the brain, the lungs and not the least the gastrointestinal and the locomotor systems. A special chapter is devoted to juvenile disease. The definitive resource on Behcet s Syndrome, this book is well suited for rheumatologists, dermatologists, ophthalmologists, neurologists, and health professionals caring for Behcet s patients."

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