This book encompasses major progress and future directions in
cytochrome P450 (P450) research. Included are contributions by
pioneers in the discovery of P450, with chapters on the molecular
and functional properties of P450 and cutting-edge applications
knowledge from various fields. P450 research has its roots in
metabolism, but the true beginning was in 1962 with the publication
by Tsuneo Omura and Ryo Sato in "The Journal of Biological
Chemistry "on their discovery of the cytochrome." "Following this
groundbreaking study, over the last half-century, research has
revealed that many forms of P450 exist in animals, plants and
microorganisms. P450 research has expanded into many different
fields including medicine, agriculture and biotechnology and has
drawn the attention of industries for its bioengineering
applications, such as drug development and creation of the blue
rose . Also, research on nuclear receptors, which has grown out of
research on the regulatory mechanisms of P450 genes, has become an
important area in biology, medical science, pharmacology and
clinical medicine for example, with recent developments in
personalized medicines. This book will draw readers into the
important and exciting world of P450 and will encourage young
students and scientists in P450 research to continue expanding the
field via new approaches."
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