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Behavioral Neurobiology of Huntington's Disease and Parkinson's Disease (Paperback, Softcover reprint of the original 1st ed. 2015)
Loot Price: R4,021
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Behavioral Neurobiology of Huntington's Disease and Parkinson's Disease (Paperback, Softcover reprint of the original 1st ed. 2015)
Series: Current Topics in Behavioral Neurosciences, 22
Expected to ship within 10 - 15 working days
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Motor dysfunction and cognitive impairment are major symptoms in
both Huntington’s Disease (HD) and Parkinson’s Disease (PD). A
breakthrough in HD research was the identification of the gene that
causes this devastating monogenetic illness. Similarly, several
genes were found to cause familial forms of PD. With their
identification, a plethora of genetic animal models has been
generated and has revolutionized the understanding of the
pathobiology and pathophysiology of these disorders. The models
allow us to study the earliest manifestations of the diseases
behaviorally and neuropathologically and help us understand how
they progress over time. Additionally, neurotoxic animal models are
still of high interest to the PD field, as they are being used to
study e.g. mitochondrial dysfunction in PD. This book focuses on
animal models of both diseases and how they have helped and will
continue to help understand the behavioral neurobiology in these
disorders.
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