There is a growing interest in the use of nanoparticles modified
with DNAs, viruses, peptides and proteins for the rational design
of nanostructured functional materials and their use in biosensor
applications. The challenge is to control the organization of
biomolecules on nanoparticles while retaining their biological
activity as potential chemical and gene therapeutics. These noble
metal nanoparticles/biomolecules conjugates have specific
properties and therefore they are attractive materials for
nanotechnology in biochemistry and medicine.
In this book, the author review work performed dealing with the
DNA structure and functionalities, interactions between DNA, noble
metal nanoparticles, surface active agents, solvents and other
additives. Particular attention is given to how the DNA's chain
length and the DNA conformation affect the interaction and
structure of the nanoconjugates and nanostructures that are formed.
Also discussed are the recent advances in the preparation,
characterization, and applications of noble metal nanoparticles
that are conjugated with DNA aptamers and oligomers. The advantages
and disadvantages of functionalized nanoparticles through various
detection modes are highlighted, including colorimetry,
fluorescence, electrochemistry, SPR, and, mass spectrometry for the
detection of small molecules and biomolecules. The functionalized
noble metal nanoparticles are selective and sensitive for the
analytes, showing their great potential in biosensing. Furthermore,
this book reviews recent progress in the area of DNA-noble metal
nanoparticles based artificial nanostructures, that is, the
preparation, collective properties, and applications of various
DNA-based nanostructures are also described.
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