Biological study of Schiff Base Metal Complexes derived from Drugs (Paperback)

The work presented concerns the preparation, characterization and biological evaluation of Cu(II) and Zn(II) complexes of Schiff bases derived from amoxycillin, cephalexin, sulphamethoxazole and trimethoprim, and salicylalde-hyde and pyridoxal. In these complexes an amino group available in the drug substances was allowed to react with salicylaldehyde and pyridoxal hydrochloride, separately, to obtain Schiff bases which were, subsequently, reacted with Cu(CH3COO)2. H2O and/or Zn(CH3COO)2.2H2O to form Schiff base metal complexes. The ligands and the complexes were characterized by microanalytical, thermogravimetric, magnetic and spectroscopic data. The geometry of the Zn(II) complexes appears to be simple square-pyramidal or octahedral. All the compounds under investigation possess antibacterial activity. The antibacterial activity showed the following trend: Cu(II)-complexes > Zn(II)-complexes > Schiff base ligands > parent xxvi drugs. The Cu(II)-complexes with the Schiff bases derived from cephalexin showed substantially enhanced activity against P. aeruginosa as compared with the parent drug.

General

Imprint:	Lap Lambert Academic Publishing
Country of origin:	United States
Release date:	March 2014
First published:	March 2014
Authors:	Iftikhar Hussain Bukhari • Muhammad Arif • Mohammad Saeed Iqbal
Dimensions:	229 x 152 x 12mm (L x W x T)
Format:	Paperback - Trade
Pages:	200
ISBN-13:	978-3-659-45946-7
Categories:	Books > Science & Mathematics > Chemistry > Inorganic chemistry > General
LSN:	3-659-45946-1
Barcode:	9783659459467

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