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Drug Repurposing and Repositioning - Workshop Summary (Paperback)
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Drug Repurposing and Repositioning - Workshop Summary (Paperback)
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Drug development can be time-consuming and expensive. Recent
estimates suggest that, on average, it takes 10 years and at least
$1 billion to bring a drug to market. Given the time and expense of
developing drugs de novo, pharmaceutical companies have become
increasingly interested in finding new uses for existing drugs - a
process referred to as drug repurposing or repositioning.
Historically, drug repurposing has been largely an unintentional,
serendipitous process that took place when a drug was found to have
an offtarget effect or a previously unrecognized on-target effect
that could be used for identifying a new indication. Perhaps the
most recognizable example of such a successful repositioning effort
is sildenafil. Originally developed as an anti-hypertensive,
sildenafil, marketed as Viagra and under other trade names, has
been repurposed for the treatment of erectile dysfunction and
pulmonary arterial hypertension. Viagra generated more than $2
billion worldwide in 2012 and has recently been studied for the
treatment of heart failure. Given the widespread interest in drug
repurposing, the Roundtable on Translating Genomic-Based Research
for Health of the Institute of Medicine hosted a workshop on June
24, 2013, in Washington, DC, to assess the current landscape of
drug repurposing activities in industry, academia, and government.
Stakeholders, including government officials, pharmaceutical
company representatives, academic researchers, regulators, funders,
and patients, were invited to present their perspectives and to
participate in workshop discussions. Drug Repurposing and
Repositioning is the summary of that workshop. This report examines
enabling tools and technology for drug repurposing; evaluates the
business models and economic incentives for pursuing a repurposing
approach; and discusses how genomic and genetic research could be
positioned to better enable a drug repurposing paradigm. Table of
Contents Front Matter 1 Introduction and Themes of the Workshop 2
The State of the Science 3 Enabling Tools and Technology 4 Value
Propositions for Drug Repurposing 5 Policy Approaches and Legal
Framework 6 Increasing the Efficiency and Success of Repurposing
References Appendix A: Workshop Agenda Appendix B: Speaker
Biographical Sketches Appendix C: Statement of Task Appendix D:
Registered Attendees
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