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Live Variola Virus - Considerations for Continuing Research (Paperback)
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Discovery Miles 10 240
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Live Variola Virus - Considerations for Continuing Research (Paperback)
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Smallpox was a devastating disease that decimated human populations
for centuries, and its eradication in 1980 was a monumental
achievement for the global health community. Since then the
remaining known strains of its causative agent, variola virus, have
been contained in two World Health Organization (WHO)-approved
repositories. In 1999, the World Health Assembly (WHA) debated the
issue of destroying these remaining strains. Arguments were
presented on the need to retain the live virus for use in
additional important research, and the decision to destroy the
virus was deferred until this research could be completed. In that
same year, the Institute of Medicine (IOM) convened a consensus
committee to explore scientific needs for the live virus. In the
ten years since the first IOM report, the scientific, political,
and regulatory environments have changed. In this new climate, the
IOM was once again tasked to consider scientific needs for live
variola virus. The committee evaluated the scientific need for live
variola virus in four areas: development of therapeutics,
development of vaccines, genomic analysis, and discovery research.
Table of Contents Front Matter Summary 1 Introduction 2 Overview of
Smallpox and Its Surveillance and Control 3 Comparative Poxvirology
4 Animal Models Using Variola and Other Orthopoxviruses 5 Genomic
Analysis 6 Development of Therapeutics 7 Development of Vaccines 8
Methods for Detection and Diagnosis 9 Discovery Research 10
Conclusions and Recommendations Appendix: Variola Strains Used to
Validate Diagnostic and Detection Assays
General
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