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Neurodegeneration - Exploring Commonalities Across Diseases: Workshop Summary (Paperback)
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Neurodegeneration - Exploring Commonalities Across Diseases: Workshop Summary (Paperback)
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Neurodegeneration: Exploring Commonalities Across Diseases is the
summary of a workshop hosted by the Institute of Medicine\'s
(IOM\'s) Forum on Neuroscience and Nervous System Disorders in
Spring 2012 to explore commonalities across neurodegenerative
diseases such as Alzheimer's disease, Parkinson's disease,
amyotrophic lateral sclerosis (ALS), and frontotemporal dementia
(FTD). Participants from academia; pharmaceutical and biotechnology
industries; government agencies such as the National Institutes of
Health and the U.S. Department of Veterans Affairs (VA); patient
advocacy groups; and private foundations presented and identified
potential opportunities for collaboration across the respective
research and development communities. This report identifies and
discusses commonalities related to genetic and cellular mechanisms,
identifies areas of fundamental science needed to facilitate
therapeutics development, and explores areas of potential
collaboration among the respective research communities.
Neurodegenerative diseases, such as Alzheimer\'s disease,
Parkinson\'s disease, ALS, and FTD, are becoming increasingly
prevalent in the United States due to an aging population.
Implications are grave for quality of life and health care costs.
Research on neurodegenerative diseases has expanded greatly over
the past four decades. Nevertheless, fundamental questions remain
about the biology of these diseases, and further insights into the
mechanisms of these diseases would help to inform the development
of effective means to prevent and to efficiently treat them. Recent
findings have revealed certain commonalities in genetic and
cellular mechanisms across neurodegenerative diseases. These
findings suggest that it might be valuable - at least in some cases
- to change the traditional way of studying these diseases by no
longer seeing each as an independent entity, but rather as clinical
variants of common cellular and molecular biological defects. This
approach could help enhance basic scientific understanding of
neurodegenerative disease, and could help with the development of
biomarkers and new therapeutics. Table of Contents Front Matter 1
Introduction 2 Rationale for Exploring Commonalities Across
Neurodegenerative Diseases 3 Protein Aggregation 4 Transmissibility
5 Mitochondrial Pathology 6 Errors in RNA 7 Closing Remarks
Appendix A: References Appendix B: Statement of Task Appendix C:
Workshop Agenda Appendix D: Registered Attendees
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