Calcium sensitizers are a new class of drug which increases the
force of contraction of the heart by increasing the calcium
sensitivity of contractile proteins. Their development represents
the first major innovation in the treatment of heart failure for
over 200 years. Unlike other drugs in this area, they do not
increase the intracellular calcium concentration and do not have
the side effects associated with that mechanism of action. These
drugs offer an exciting alternative approach to the treatment of
heart failure, and this volume provides an authoritative overview
of the physiology, biochemistry, and clinical issues involved. It
will be of interest to pharmacologists, research and clinical
cardiologists, and physiologists.
General
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