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Nicotine Psychopharmacology (Hardcover, 2009 ed.)
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Nicotine Psychopharmacology (Hardcover, 2009 ed.)
Series: Handbook of Experimental Pharmacology, 192
Expected to ship within 12 - 17 working days
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The fact that tobacco ingestion can affect how people feel and
think has been known for millennia, placing the plant among those
used spiritually, honori?cally, and habitually (Corti 1931; Wilbert
1987). However, the conclusion that nicotine - counted for many of
these psychopharmacological effects did not emerge until the
nineteenth century (Langley 1905). This was elegantly described by
Lewin in 1931 as follows: "The decisive factor in the effects of
tobacco, desired or undesired, is nicotine. . . "(Lewin 1998). The
use of nicotine as a pharmacological probe to und- stand
physiological functioning at the dawn of the twentieth century was
a landmark in the birth of modern neuropharmacology (Limbird 2004;
Halliwell 2007), and led the pioneering researcher John Langley to
conclude that there must exist some "- ceptive substance" to
explain the diverse actions of various substances, including
nicotine, when applied to muscle tissue (Langley 1905). Research on
tobacco and nicotine progressed throughout the twentieth century,
but much of this was from a general pharmacological and
toxicological rather than a psychopharmacological perspective
(Larson et al. 1961). There was some attention to the effects
related to addiction, such as euphoria (Johnston 1941), tolerance
(Lewin 1931), and withdrawal (Finnegan et al. 1945), but outside of
research supported by the tobacco industry, addiction and
psychopharmacology were not major foci for research (Slade et al.
1995; Hurt and Robertson 1998; Henning?eld et al. 2006; Henning?eld
and Hartel 1999; Larson et al. 1961).
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