GABA (gamma-aminobutyric acid) is the main neurotransmitter
regulating sleep. The majority of drugs presently in use for the
treatment of sleep disorders act by enhancing GABAergic neuronal
inhibition. The GABA system is, therefore, of prime clinical
relevance for the therapy of insomnia. The focus of this volume is
on the neuropsychopharmacology and the clinical impact of the GABA
system in regulating sleep and wakefulness. It presents molecular,
neuropharmacological, systems-biological and clinical approaches to
the understanding of the mechanism of action of GABA and GABAergic
drugs. It also explores the role of GABA in the basic drives that
affect sleep, and the influences that adapt sleep and wakefulness
to external events.
General
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