Research on muscarinic receptors is advancing at an extraordinary
rate. Ten years ago, the existence of muscarinic receptor sub types
was a logical assumption with only scattered experimen tal support.
The discovery that pirenzepine recognized apparent heterogeneity in
muscarinic binding sites infused new life into the problem of
subclassifying muscarinic receptors. Simultaneous advances in
molecular biology created a frenzy to clone cell sur face
receptors. The muscarinic receptor succumbed surprisingly quickly,
revealing its structure and that of at least four closely related
gene products within a year. Our hope of obtaining clear evidence
for muscarinic receptor subtypes was answered with a vengeance. Now
a family of muscarinic receptors sits before us, asking to be
understood. The bounty is as attractive to those who have not
previously studied muscarinic receptors as to those who have
dedicated their research careers to this subject. The goal of this
book is to ensure that the new generation of research will profit
from the wisdom of the past. The tools of molecular biology are
well suited to the tasks of characteriz ing the pharmacology,
function, and regulation of the distinct muscarinic receptor
subtypes. However, efficient and intelligent use of these tools is
not possible, unless one understands the properties of the
receptor, the molecular mechanisms by which it couples to
effectors, and the ways that it is regulated."
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