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Books > Science & Mathematics > Biology, life sciences > Molecular biology
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Molecular Cloning of Hormone Genes (Hardcover, 1987 ed.)
Loot Price: R6,278
Discovery Miles 62 780
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Molecular Cloning of Hormone Genes (Hardcover, 1987 ed.)
Series: Molecular Biology and Biophysics
Expected to ship within 12 - 17 working days
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Total price: R6,298
Discovery Miles: 62 980
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The peptide hormones are small proteins that regulate cellular
metabolism through their specific interactions with tissues of the
endocrine, nervous, and immune systems, as well as in embry onic
development. During the past ten years, refinements in the
techniques of recombinant DNA technology have resulted in the
cloning of genes encoding approximately 50 different hormonal and
regulatory peptides, including those in which the peptides
themselves and the mRNAs encoding the peptides are present in only
trace amounts in the tissues of origin. In addition to provid ing
the coding sequences of recognized hormonal and regulatory
peptides, gene sequencing has uncovered new bioactive peptides
encoded in the precursor pro hormones that are then liberated along
with the hormonal peptides during cellular cleavages of the
precursors. The encoding of multiple peptides in a single mono
cistronic mRNA appears to be a genetic mechanism for the gener
ation of biologic diversification without requiring amplification
of gene sequences. Two of the objectives in the assembly of this
book are to pre sent, in one volume, the known primary structures
of the genes encoding several of the polypeptide hormones and
related regulatory peptides, and to provide an account of the
various ap proaches that have been used to identify and select the
cloned genes encoding these polypeptides. The contents of the two
in troductory chapters are intended to provide the reader with a
brief background of the approaches to gene cloning and the struc
ture and expression of hormone-encoding genes."
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