Toxicokinetics in Risk Assessment discusses the noncancer risk
assessment process and its reliance on uncertainty factors in order
to facilitate the continued study and refinement of the scientific
basis for health risk assessment. This text clearly demonstrates
the application of physiologically-based pharmacokinetic (PBPK)
modeling in human health risk assessment, as well as methods for
data generation, extrapolation, and inclusion of laboratory results
for chemical metabolism and computer-based predictions of
biochemical constants to address estimates of variability between
experimental animals and humans. This guide also includes recent
examples of the use of toxicokinetic information to successfully
replace default values for uncertainty factors with data-derived
factors in risk assessments developed by the US Environmental
Protection Agency.
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