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Normal Testicular Descent and the Aetiology of Cryptorchidism (Paperback, Softcover reprint of the original 1st ed. 1996)
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Normal Testicular Descent and the Aetiology of Cryptorchidism (Paperback, Softcover reprint of the original 1st ed. 1996)
Series: Advances in Anatomy, Embryology and Cell Biology, 132
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Cryptorchidism remains a common but poorly understood anomaly
affecting 2%-5% of children. Major controversies exist over the
timing and type of treat ment (i. e. surgical vs hormonal therapy)
and whether intervention prevents sub sequent infertility and
testicular cancer. Part of the dilemma is caused by lack of
understanding of the normal process of descent, despite intensive
research and study since the eighteenth century, when Hunter and
von Haller first described the gubernaculum (caudal genito-inguinal
ligament) and processus vaginalis (Williams and Hutson 1991a). More
needs to be known, not only of the normal mechanism, but also of
the ways that it can be deranged to produce undescended testes.
This review describes the recent results of studies on normal
descent, with emphasis on our studies of the different stages of
descent. As the reader will appreciate, the ever-more complex
models proposed to account for normal tes ticular descent predict
that undescended testes will be caused by a multitude of anomalies
affecting different stages of the process. A description is given
of current hypotheses of the aetiology of cryptorchidism,
correlating these with studies of cryptorchid animal models. For a
more detailed description of the numerous ideas about the
mechanism, the reader is referred to Heyns and Hutson (1995) and
other monographs (Fonkalsrud and Mengel 1981; Abney and Keel
1989)."
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