Real-world and clinical trial data support that clozapine is the
only effective antipsychotic for treatment resistant schizophrenia
and other severe mental illnesses. Clozapine also reduces rates of
suicidality, psychiatric hospitalization and all-cause mortality.
However, clozapine is underutilized for two reasons:
misunderstandings of its efficacy benefits and misapprehension of,
limited knowledge or misinformation about the management of
treatment related risks and adverse effects. In response to
worldwide efforts to promote clozapine use, this user-friendly
Handbook provides clinicians with evidence-based approaches for
patient management, as well as logical approaches to the management
of clinical situations and adverse effects. It outlines clearly the
rationale for specific management decisions and prioritises the
options based on this logic. This Handbook is designed for use by
clinicians worldwide and is essential reading for all mental health
care professionals.
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