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Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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Mitochondria and the Heart (Hardcover, 2005 ed.)
Loot Price: R5,789
Discovery Miles 57 890
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Mitochondria and the Heart (Hardcover, 2005 ed.)
Series: Developments in Cardiovascular Medicine, 256
Expected to ship within 10 - 15 working days
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Mitochondria have been pivotal in the development of some of the
most important ideas in modern biology. Since the discovery that
the organelle has its own DNA and specific mutations were found in
association with neuromuscular and cardiovascular diseases and with
aging, an extraordi-nary number of publications have followed, and
the term mitochondrial medicine was coined. Furthermore, our
understanding of the multiple roles that mitochondria play in
cardiac cell homeostasis opened the door for intensive
experimentation to understand the pathogenesis and to find new
treatments for cardiovascular diseases. Besides its role in
adenosine triphosphate generation, mitochondria regu-late a complex
network of cellular interactions, involving (1) generation and
detoxification of reactive oxygen species, including superoxide
anion, hy-drogen peroxide, and hydroxyl radical; (2) maintenance of
the antioxidant glutathione in a reduced state and adequate level
of mitochondrial matrix superoxide dismutase; (3) cytoplasmic
calcium homeostasis, particularly under conditions of cellular
calcium loading; (4) transport of metabolites between cytoplasm and
matrix; (5) both programmed (apoptosis) and necrotic cell death;
and (6) cell growth and development. It is therefore not surprising
that this organelle has come to be the center stage in many current
investigations of cardiovascular diseases, aging, and agi- related
disease. Concomitant with these advances, an impressive effort is
under- way for the development of new tools and methodologies to
study mitochondrial structure and function, including powerful ways
to visualize, monitor, and alter the organelle function to assess
the genetic consequences of these perturbations.
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