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Cyclic Nucleotide Phosphodiesterases in Health and Disease (Paperback)
Loot Price: R1,861
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Cyclic Nucleotide Phosphodiesterases in Health and Disease (Paperback)
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Since the last major compendium dedicated to cyclic nucleotide
phosphodiesterases (PDEs) was published over 15 years ago, an
enormous amount of progress has occurred in the field. There is
great need for a centralized source for key information in this
burgeoning and therapeutically important area of medical research.
Cyclic Nucleotide Phosphodiesterases in Health and Disease provides
an integrated volume covering PDE biology from genes to organisms.
It examines phosphodiesterases as pharmacological targets as well
as the development of specific PDE inhibitors as therapeutic
agents. With contributions from pioneers in the field, individual
chapters describe one of the 11 known mammalian PDE families
including the molecular characteristics, structure, function, and
traits unique to each. Characteristics of PDEs from lower organisms
are also the subject of other chapters since they provide key
insights into PDE functions and are also pharmacological targets
for treatment of a variety of diseases in humans and domestic
animals. Chapters on the current biomedical and therapeutic
research on PDEs include studies on gene-targeted knockout
strategies and compartmentation in cyclic nucleotide signaling. By
unraveling the unique cellular roles for different PDEs, scientists
are beginning to open the door to the therapeutic use of PDE
inhibitors for the treatment of a number of pathological conditions
including asthma and inflammation, pulmonary hypertension, erectile
dysfunction, and stroke. By collating current information into a
coherent and coordinated perspective, Cyclic Nucleotide
Phosphodiesterases in Health and Disease provides an invaluable
reference for industry and clinical scientists and points toward
future directions of research and therapeutic advancements in
developing selective inhibitors for these various enzymes.
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