Cerebrospinal fluid (CSF) functions to bathe the brain and
spinal cord and is vital for the maintenance of fluid homeostasis
within the central nervous system (CNS). The production of CSF by
the choroid plexus is tightly regulated, providing the necessary
nutrients and removing waste that may compromise the normal
homeostasis of the CNS. Though growth factors and neuropeptide
hormones produced and secreted by the choroid plexus are known to
play critical roles in CNS homeostasis, the choroid plexus and CSF
have been one of the most understudied tissues in neuroscience.
Recent work has begun to elucidate how the choroid plexus and
CSF regulate development and disease in ways that extend far beyond
traditional neurobiology roles. This book presents novel and
exciting findings in the area of the choroid plexus and CSF in
brain development and introduces its link to multiple disease
disciplines, including cancer biology and neurodegeneration. Each
chapter is written by an expert in his/her field and provides a
comprehensive review of the anatomy, development, structure, and
function of the choroid plexus and CSF in the nervous system, with
particular focus on multiple disease disciplines, including primary
brain tumours, metastases, Multiple Sclerosis, and Alzheimer s
Disease. This book provides a link between the choroid plexus, the
clinical problems arising from its dysfunction, and investigational
approaches and techniques that will help foster future research
with high translational value.
The Choroid Plexus and Cerebrospinal Fluid 1e combines new and
established work to allow for cross-disciplinary discussion and
showcase newfound excitement surrounding the choroid plexus and
CSF. This book is of great utility to neuroscientists interested in
biological questions about cancer, Multiple Sclerosis, Alzheimer s,
choroid plexus, or CSF research, and especially for researchers
looking to expand their research into later stages of their disease
of interest, such as metastasis. The focus on the choroid plexus
provides a practical resource on modeling clinical issues
influenced by this brain region for researchers from students to
principal investigators. No other resource is currently available
which addresses these issues in this fashion, and so this volume
fills a much needed niche in the literature.
* Presents recent progress made in the research of choroid
plexus and cerebrospinal fluid across multi-disciplinary fields,
including neuroscience, cancer biology, immunology
* Numerous illustrations of light, fluorescent, and electron
micrographs
* Data Analysis boxes in each chapter help with data
interpretation andoffer guidelines on how best to represent
results
* Includes chapters written by prominent researchers in the
field "
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