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Chest Pain with Normal Coronary Angiograms: Pathogenesis, Diagnosis and Management (Hardcover, 1999 ed.)
Loot Price: R5,897
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Chest Pain with Normal Coronary Angiograms: Pathogenesis, Diagnosis and Management (Hardcover, 1999 ed.)
Series: Developments in Cardiovascular Medicine, 213
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This book is timely and challenging. Within its pages are
commentaries and opinions on the scientific background and
explanatory ideas for a complex of symptoms and investigations
known as syndrome X. The commonest cause by far of angina pectoris
is coronary artery obstruction due to atheromatous lesions both
within the wall of the artery and intruding into the lumen; in such
patients it is expected that there maybe ST segment depression on
atrial pacing or on an exercise test indicating myocardial
ischemia. Syndrome X was a term first used in an editorial written
by Kemp in 1973. He was referring to patients in group X in a paper
from Arbogast and Bourassa. Patients in group X had three features,
namely angina as judged on a clinical history, alterations of the
ST segment on the electrocardiogram during atrial pacing and smooth
unobstructed coronary arteries (presumed normal) as assessed by the
technique of coronary angiography. The changes on the
electrocardiogram, conventionally indicative of myocardial
ischemia, could not be explained on the basis of any abnormality of
the coronary arteries and Kemp named the complex of fmdings
syndrome X because of this seeming paradox and the lack of a single
explanation. In the last thirty-one years there has been
substantial scientific interest in this syndrome giving rise to a
large number of publications. The name syndrome X has led to
considerable confusion. Physicians are familiar with the X
chromosome and with X linked congenital disorders.
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