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Malaria (Paperback)
Loot Price: R2,047
Discovery Miles 20 470
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Malaria (Paperback)
Series: Colloquium Series on Integrated Systems Physiology: From Molecule to Function
Expected to ship within 10 - 15 working days
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This ebook describes the pathogenesis of malaria and the major
consequences of the parasitism to the vertebrate host. Malaria is
one of the oldest infectious diseases of mankind, which still
exerts a high burden on human health and society. It is caused by
parasites of the genus Plasmodium, and transmitted by Anopheline
mosquitoes. Despite several decades of intensive control efforts,
malaria remains widely distributed with an estimated 3.3 billion of
the world's population at risk of infection. The malaria life cycle
is extremely complex and the blood stage parasites are responsible
for all the symptoms and pathology of malaria. Because of this
strict association between the parasites and red cells, there are
numerous consequences to the host's blood extending far beyond the
direct effect of parasitized RBCs. Chapter 1 of the ebook
summarizes the different clinical and pathogenic features of the
disease, comparing the disease caused by Plasmodium falciparum and
Plasmodium vivax, the two prevalent malaria species. This chapter
is the basis of the remaining chapters, in which the different
mechanisms of the pathogenesis of malaria are discussed in greater
depth. In this direction, in Chapter 2 we discuss the role of host
and parasite genetic diversity, which determines the malaria
pathogenesis. Chapter 3 discusses the immune mechanisms associated
with malarial anemia, a multifactorial clinical outcome which has
not been fully addressed. In Chapter 4 we focus on the immune
response associated with parasite control and microvascular damage.
Chapter 5 presents information about epidemiology, clinical
presentation, diagnosis, and management of cerebral malaria (CM),
the most severe neurological complication of Plasmodium falciparum
infection. Understanding how an intraerythrocytic parasite, which
remains within the vascular space of the brain, causes profound
neurological effects will be explained in Chapter 6, which presents
the interesting mechanism of interaction between infected red blood
cells (RBC) and the blood brain barrier (BBB). Finally in Chapter 7
we conclude with a discussion of the mechanisms of persistent
cognitive and memory impairment associated with cerebral malaria.
We hope that this ebook will be useful for students, professionals
and researchers by providing an up-to-date summary of the factors
that determine Plasmodium-associated morbidity and severe disease.
Table of Contents: Malaria Pathogenesis / Possible Mechanisms to
Explain Plasmodium Immunopathogenesis / Malarial Anemia: A
Multifactorial Hematological Outcome / Immune Response to Malaria
Blood Stage / Human Cerebral Malaria and Experimental Models /
Blood-Brain Barrier Disruption in Cerebral Malaria / Persisent
Cognitive and Memory Impairment after Cerebral Malaria /
Bibliography
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