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Essential Hypertension - An International Symposium. Berne, June 7th-10th, 1960 Sponsored by CIBA (German, Paperback, Softcover Reprint of the Original 1st 1960 ed.)
Loot Price: R1,697
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Essential Hypertension - An International Symposium. Berne, June 7th-10th, 1960 Sponsored by CIBA (German, Paperback, Softcover Reprint of the Original 1st 1960 ed.)
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In the span of a few short years the therapeutic management of
essential hypertension has been transformed from one of gross
empiricism to that of a stable, rational approach based on
established pharmacological principles. This success has required a
close liaison among the disciplines of chemistry, of pharmacology,
and of the clinic, for the niceties and fine nuances governing the
relationship between chemical structure and type of biological
activity of a compound are all too elusive for charting a reliable
course through unfamiliar synthetic molecular configurations.
Although autonomic nervous overactivity had never been demonstrably
implicated as an etiological factor in essential hypertension, it
had been realized earlier that suppression of this system by
pharmacological means offered potential therapeutic benefit.
Unfortunately, early investigative work had not yielded specific
potent autonomic blocking agents with suf- ficiently wide
therapeutic indices to be suitable for human use. The initial
successful surgical approach to the problem of sympathetic nervous
dampen- ing by means of a dorsal thoracolumbar sympathectomy
established the validity of such a procedure and laid the
groundwork for an ultimate pharmacological approach. Among the
effective agents which have been discussed, an action either
directly or indirectly upon the sympathetic nervous system or upon
the neurohumors which it elaborates has been a common denominator.
Such an occurrence inevitably poses the question as to whether such
a common denominator has basic meaning or is merely coincidental
with respect to the mode of action of the drug.
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